Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 7/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.32 |
| ▸ | PHGDH | O43175 | 1/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL28105921 | 0.85 | ALOX5 (0.36) | NOS2ALOX5 | |
| SCHEMBL3910736 | 0.76 | NOS2 (0.43) | NOS2PHGDHNOS3NOS1 | |
| SCHEMBL3074753 | 0.74 | PHGDH (0.44) | NOS2ALOX5PHGDH | |
| SCHEMBL27971230 | 0.74 | NOS2 (0.42) | NOS2ALOX5PHGDHNOS3NOS1 | |
| SCHEMBL1991457 | 0.74 | PHGDH (0.39) | NOS2PHGDH | |
| SCHEMBL14538277 | 0.74 | ALOX5 (0.41) | NOS2ALOX5 | |
| SCHEMBL17913064 | 0.72 | PHGDH (0.43) | ALOX5PHGDH | |
| SCHEMBL10431258 | 0.72 | FAAH (0.45) | NOS2PHGDH | |
| SCHEMBL4092988 | 0.72 | FAAH (0.45) | NOS2PHGDH | |
| SCHEMBL27874517 | 0.72 | ALOX5 (0.43) | NOS2ALOX5PHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583522-A1 | USE OF CYCLIN D1 INHIBITORS | Forskarpatent i Syd AB (SE) | 2005-10-12 | — | — | EP | claimed |
| WO-2004062654-A1 | USE OF CYCLIN D1 INHIBITORS | FORSKARPATENT I SYD AB (SE) | 2004-07-29 | — | — | WO | claimed |
| EP-1357881-A4 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | QUARK PHARMACEUTICALS INC (US) | 2009-02-18 | — | — | EP | disclosed |
| US-6696454-B2 | ADMINISTERING AN INHIBITOR OF SPERMIDINE BIOSYNTHESIS; PREFERRED ARE DCHA (DICYCLOHEXYLAMINE), ADODATO, AND TRANS-4-METHYLCYCLOHEXYLAMINE (4MCHA) | QUARK BIOTECH, INC. | 2004-02-24 | — | — | US | disclosed |
| EP-1357881-A2 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | Quark Biotech, Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| US-20020160978-A1 | Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation | QUARK PHARMACEUTICALS, INC. | 2002-10-31 | — | — | US | disclosed |
| WO-2002058623-A2 | INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION | QUARK BIOTECH, INC. (US) | 2002-08-01 | — | — | WO | disclosed |