Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.63 |
| ▸ | HTR6 | P50406 | 2/20 | 0.63 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.61 |
| ▸ | TUBB | P07437 | 2/20 | 0.61 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.61 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.61 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.61 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.61 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.61 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.61 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.61 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.61 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.61 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.61 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.61 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.61 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9370956 | 0.86 | KDM4E (0.60) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL2880010 | 0.84 | KDM4E (0.66) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL3276393 | 0.83 | TUBB4A (0.67) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL7534562 | 0.83 | ALDH1A1 (0.71) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL34463677 | 0.83 | MEN1 (0.58) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3879382 | 0.83 | MEN1 (0.58) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL829961 | 0.82 | ALDH1A1 (0.71) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL4332747 | 0.82 | KDM4E (0.70) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL4740841 | 0.82 | KDM4E (0.63) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL2724382 | 0.82 | KDM4E (0.63) | KDM4EHTR6TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025043115-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | TAXIS PHARMACEUTICALS, INC. (US) | 2025-02-27 | — | — | WO | disclosed |
| US-20240239771-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | TAXIS PHARMACEUTICALS, INC. | 2024-07-18 | — | — | US | disclosed |
| US-20240239771-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | TAXIS PHARMACEUTICALS, INC. | 2024-07-18 | — | — | US | disclosed |
| US-20240239771-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | TAXIS PHARMACEUTICALS, INC. | 2024-07-18 | — | — | US | disclosed |
| US-11826357-B2 | Bacterial efflux pump inhibitors | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2023-11-28 | — | — | US | disclosed |
| US-11826357-B2 | Bacterial efflux pump inhibitors | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2023-11-28 | — | — | US | disclosed |
| US-11826357-B2 | Bacterial efflux pump inhibitors | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2023-11-28 | — | — | US | disclosed |
| WO-2021243273-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | TAXIS PHARMACEUTICALS, INC. (US) | 2021-12-02 | — | — | WO | disclosed |
| WO-2021243273-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | TAXIS PHARMACEUTICALS, INC. (US) | 2021-12-02 | — | — | WO | disclosed |
| WO-2021216660-A1 | 5-MEMBERED HETEROARYL CARBOXAMIDE COMPOUNDS FOR TREATMENT OF HBV | ASSEMBLY BIOSCIENCES, INC. (US) | 2021-10-28 | — | — | WO | disclosed |
| US-5684032-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC, ANTIASTHMATIC AGENTS AND RESPIRATORY DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0800389-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996018393-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-06-20 | — | — | WO | disclosed |
| EP-0676959-A4 | ENDOTHELIN RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM CORP (US) | 1996-01-03 | — | — | EP | disclosed |
| EP-0676959-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-18 | — | — | EP | disclosed |
| EP-0526478-B1 | 3-INDOLYL THIOACETATE DERIVATIVES | MERRELL DOW PHARMA (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1994014434-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-07 | — | — | WO | disclosed |
| EP-0526478-A1 | 3-INDOLYL THIOACETATE DERIVATIVES. | MERRELL DOW PHARMA (US) | 1993-02-10 | — | — | EP | disclosed |
| WO-1991016307-A1 | 3-INDOLYL THIOACETATE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-10-31 | — | — | WO | disclosed |
| US-5051442-A | 3-indolyl thioacetate derivatives and NMDA receptor antagonistic use thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11826357-B2 | Bacterial efflux pump inhibitors | ABCB11, ABCB1, SLC47A1 | KDM4E 4252/4885HTR6 3490/4885TUBB4A 1627/4885 |
| US-20240239771-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | ABCB11, ABCB1, SLC47A1 | KDM4E 4432/4885HTR6 3328/4885TUBB4A 1593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.