Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.63 |
| ▸ | HTR6 | P50406 | 2/20 | 0.63 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.61 |
| ▸ | TUBB | P07437 | 2/20 | 0.61 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.61 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.61 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.61 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.61 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.61 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.61 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.61 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.61 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.61 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.61 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.61 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.61 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31318102 | 1.00 | KDM4E (0.63) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL2880010 | 0.84 | KDM4E (0.66) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL7534562 | 0.83 | ALDH1A1 (0.71) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL3276393 | 0.83 | TUBB4A (0.67) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL697252 | 0.83 | MAPT (0.59) | KDM4ETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL24375425 | 0.82 | KMT2A (0.58) | KDM4EMAPTALDH1A1HPGDTSHR | |
| SCHEMBL43369 | 0.82 | KDM4E (0.63) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL2724382 | 0.82 | KDM4E (0.63) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL4332747 | 0.82 | KDM4E (0.70) | KDM4EHTR6TUBB4ATUBBTUBA3C | |
| SCHEMBL30797259 | 0.82 | KDM4E (0.63) | KDM4EHTR6TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120004902-A | Heteroaryl heterocycles and uses thereof | 和记黄埔医药（上海）有限公司 | 2025-05-16 | — | — | CN | disclosed |
| CN-119930630-A | Heteroaryl heterocycles and uses thereof | 和记黄埔医药（上海）有限公司 | 2025-05-06 | — | — | CN | disclosed |
| CN-119925375-A | Heteroaryl heterocycles and uses thereof | 和记黄埔医药（上海）有限公司 | 2025-05-06 | — | — | CN | disclosed |
| CN-115151535-B | Heteroaryl heterocycles and uses thereof | 和记黄埔医药（上海）有限公司 | 2025-01-10 | — | — | CN | disclosed |
| US-12173008-B2 | Substituted piperazines as BTK inhibitors | HUTCHISON MEDIPHARMA LIMITED (CN) | 2024-12-24 | — | — | US | disclosed |
| US-20230382916-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2023-11-30 | — | — | US | disclosed |
| US-20230382916-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2023-11-30 | — | — | US | disclosed |
| US-20230382916-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2023-11-30 | — | — | US | disclosed |
| CN-116568687-A | Heteroaryl heterocycles and uses thereof | 和记黄埔医药（上海）有限公司 | 2023-08-08 | — | — | CN | disclosed |
| EP-4214206-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | Hutchison Medipharma Limited (CN) | 2023-07-26 | — | — | EP | disclosed |
| US-11655254-B2 | Substituted piperazines as BTK inhibitors | HUTCHISON MEDIPHARMA LIMITED (CN) | 2023-05-23 | — | — | US | disclosed |
| US-20230043030-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2023-02-09 | — | — | US | disclosed |
| US-11478474-B2 | 2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-7,8-dihydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one as a BTK inhibitor | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-10-25 | — | — | US | disclosed |
| US-20220332719-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-10-20 | — | — | US | disclosed |
| CN-115151535-A | Heteroaryl heterocyclic compounds and uses thereof | 和记黄埔医药（上海）有限公司 | 2022-10-04 | — | — | CN | disclosed |
| US-20220125785-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-04-28 | — | — | US | disclosed |
| WO-2022057894-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-03-24 | — | — | WO | disclosed |
| EP-1330454-A4 | BENZOPYRANYL HETEROCYCLE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DONGBU HANNONG CHEMICAL CO LTD (KR) | 2008-03-19 | — | — | EP | disclosed |
| EP-1330454-A1 | BENZOPYRANYL HETEROCYCLE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dongbu Hannong Chemical Co., Ltd. (KR) | 2003-07-30 | — | — | EP | disclosed |
| WO-2002030925-A1 | BENZOPYRANYL HETEROCYCLE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DONGBU HANNONG CHEMICAL CO., LTD (KR) | 2002-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230382916-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | CYP3A43, CYP3A5, CYP3A7 | KDM4E 3625/4885HTR6 937/4885TUBB4A 1062/4885 |
| US-20220125785-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | CYP3A4, CYP4B1, CYP3A5 | KDM4E 1963/4885HTR6 102/4885TUBB4A 840/4885 |
| US-12173008-B2 | Substituted piperazines as BTK inhibitors | BTK, SYK, ABL1 | KDM4E 644/4885HTR6 3306/4885TUBB4A 2570/4885 |
| US-11478474-B2 | 2-(3′-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-7,8-dihydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one as a BTK inhibitor | BTK, SYK, LCK | KDM4E 292/4885HTR6 1651/4885TUBB4A 2524/4885 |
| US-11655254-B2 | Substituted piperazines as BTK inhibitors | BTK, SYK, LYN | KDM4E 824/4885HTR6 3814/4885TUBB4A 2216/4885 |
| US-20230043030-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | CYP3A43, CYP3A5, CYP11B2 | KDM4E 3801/4885HTR6 516/4885TUBB4A 1462/4885 |
| US-20220332719-A1 | HETEROARYL HETEROCYCLIC COMPOUNDS AND USES THEREOF | BTK, SYK, LYN | KDM4E 1451/4885HTR6 2944/4885TUBB4A 2774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.