Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL1938419 | 1.00 | ALDH1A1 (0.56) | ALDH1A1TSHRHSD17B10TDP1SMN1; SMN2 | |
| Dioxane SCHEMBL9508711 | 0.88 | ALDH1A1 (0.62) | ALDH1A1TSHRHSD17B10TDP1SMN1; SMN2 | |
| Oxirane SCHEMBL8581231 | 0.85 | ALDH1A1 (0.67) | ALDH1A1TSHRHSD17B10TDP1SMN1; SMN2 | |
| SCHEMBL28288392 | 0.84 | ALDH1A1 (0.50) | ALDH1A1TSHRHSD17B10TDP1SMN1; SMN2 | |
| Tetrahydrofuran SCHEMBL10761380 | 0.83 | ALDH1A1 (0.56) | ALDH1A1TSHRHSD17B10TDP1SMN1; SMN2 | |
| SCHEMBL9508706 | 0.83 | ALDH1A1 (0.56) | ALDH1A1TSHRHSD17B10TDP1 | |
| Tetrahydrofuran SCHEMBL165529 | 0.82 | — | — | |
| Pyridine SCHEMBL15233785 | 0.82 | TSHR (0.37) | ALDH1A1TSHRTDP1MEN1KMT2A | |
| Tetrahydrofuran SCHEMBL29171726 | 0.81 | ALDH1A1 (0.53) | ALDH1A1TSHRHSD17B10TDP1SMN1; SMN2 | |
| Tetrahydrofuran SCHEMBL28969290 | 0.80 | ALDH1A1 (0.54) | ALDH1A1TSHRSMN1; SMN2GLALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064313-A2 | AUTOMATED PARALLEL OLIGONUCLEOTIDE SYNTHESIS | Centocor, Inc. (US) | 2009-06-03 | — | — | EP | disclosed |
| US-20080177054-A1 | Automated Parallel Oligonucleotide Synthesis | EVANS DAVID | 2008-07-24 | — | — | US | disclosed |
| WO-2008028024-A2 | AUTOMATED PARALLEL OLIGONUCLEOTIDE SYNTHESIS | CENTOCOR, INC. (US) | 2008-03-06 | — | — | WO | disclosed |
| EP-1180113-A4 | OLIGONUCLEOTIDES HAVING A-DNA FORM AND B-DNA FORM CONFORMATIONAL GEOMETRY | ISIS PHARMACEUTICALS INC (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-1180113-A1 | OLIGONUCLEOTIDES HAVING A-DNA FORM AND B-DNA FORM CONFORMATIONAL GEOMETRY | ISIS PHARMACEUTICALS, INC. (US) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000066609-A1 | OLIGONUCLEOTIDES HAVING A-DNA FORM AND B-DNA FORM CONFORMATIONAL GEOMETRY | ISIS PHARMACEUTICALS, INC. (US) | 2000-11-09 | — | — | WO | disclosed |