Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4327176 | 0.93 | HRH3 (0.34) | MCHR1HRH3 | |
| SCHEMBL4324395 | 0.92 | KDM4E (0.38) | OPRM1CHRM4MCHR1NPBWR1FFAR4 | |
| SCHEMBL4339066 | 0.92 | OPRM1 (0.38) | OPRM1CHRM4MCHR1NPBWR1HRH3 | |
| SCHEMBL4323056 | 0.91 | OPRM1 (0.38) | OPRM1CHRM4MCHR1NPBWR1 | |
| SCHEMBL8260395 | 0.85 | HTR1A (0.36) | HRH3 | |
| SCHEMBL4334455 | 0.85 | KDM4E (0.39) | MCHR1 | |
| SCHEMBL8254873 | 0.85 | DRD2 (0.41) | HRH3 | |
| SCHEMBL4326768 | 0.84 | CHRM4 (0.41) | CHRM4MCHR1 | |
| SCHEMBL4325423 | 0.81 | LIPE (0.39) | OPRM1CHRM4MCHR1NPBWR1 | |
| SCHEMBL4318722 | 0.80 | CHRM4 (0.40) | OPRM1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069340-A1 | Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders | ASTRAZENECA AB (SE) | 2009-03-12 | — | — | US | disclosed |
| US-20090069340-A1 | Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders | ASTRAZENECA AB (SE) | 2009-03-12 | — | — | US | disclosed |
| US-20090069340-A1 | Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders | ASTRAZENECA AB (SE) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069340-A1 | Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders | GRIN1, GRM1, GRIN3A | OPRM1 264/4885CHRM4 85/4885MCHR1 255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.