SCHEMBL433842

SCHEMBL433842

C[Si](C)(C)CSc1ccccn1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EHMT2 Q96KQ7 1/20 0.52
EHMT1 Q9H9B1 1/20 0.52
APOBEC3G Q9HC16 1/20 0.52
RAB9A P51151 6/20 0.49
ALDH1A1 P00352 5/20 0.49
NPC1 O15118 5/20 0.49
TDP1 Q9NUW8 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
LMNA P02545 2/20 0.47
KMT2A Q03164 3/20 0.46
HPGD P15428 3/20 0.46
MEN1 O00255 2/20 0.46
HSD17B10 Q99714 2/20 0.46
TSHR P16473 1/20 0.46
KDM4E B2RXH2 1/20 0.46
ALOX15 P16050 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
MAPT P10636 2/20 0.45
PKM P14618 1/20 0.45
POLB P06746 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31403216 0.82 ALDH1A1 (0.56) EHMT2EHMT1APOBEC3GRAB9AALDH1A1
SCHEMBL18227275 0.80 LMNA (0.45) EHMT2EHMT1APOBEC3GRAB9AALDH1A1
SCHEMBL8309026 0.78
SCHEMBL2638447 0.78
SCHEMBL7205329 0.78 EHMT2 (0.61) EHMT2EHMT1APOBEC3GRAB9AALDH1A1
SCHEMBL27507873 0.77 EHMT2 (0.54) EHMT2EHMT1APOBEC3GRAB9AALDH1A1
SCHEMBL2608954 0.75 KMT2A (0.58) EHMT2EHMT1APOBEC3GRAB9AALDH1A1
SCHEMBL5020551 0.75 ALDH1A1 (0.58) EHMT2EHMT1APOBEC3GRAB9AALDH1A1
SCHEMBL4687320 0.74
SCHEMBL3063913 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2595957-B1 PYRIDIN-2-YL SULFANYL ACID ESTERS AND PROCESS FOR THE PREPARATION THEREOF COUNCIL SCIENT IND RES (IN) 2014-08-13 EP disclosed
US-8680288-B2 Pyridin-2yl sulfanyl acid esters and process for the preparation thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2014-03-25 US disclosed
EP-2595957-A1 PYRIDIN- 2 - YL SULFANYL ACID ESTERS AND PROCESS FOR THE PREPARATION THEREOF Council of Scientific & Industrial Research (IN) 2013-05-29 EP disclosed
US-20130131350-A1 PYRIDIN-2YL SULFANYL ACID ESTERS AND PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2013-05-23 US disclosed
WO-2012011123-A1 PYRIDIN- 2 - YL SULFANYL ACID ESTERS AND PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2012-01-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130131350-A1 PYRIDIN-2YL SULFANYL ACID ESTERS AND PROCESS FOR THE PREPARATION THEREOF VCAM1, ICAM1, CCL5 EHMT2 2019/4885EHMT1 980/4885APOBEC3G 4700/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.