Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4338472 | 1.00 | ALDH1A1 (0.52) | ALDH1A1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL4333541 | 0.83 | HTT (0.50) | ALDH1A1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL4338959 | 0.83 | HTT (0.50) | ALDH1A1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL10418997 | 0.77 | HTT (0.63) | ALDH1A1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL4337912 | 0.76 | RAB9A (0.71) | ALDH1A1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL11671841 | 0.74 | ALPL (0.70) | ALDH1A1SMN1; SMN2MAPTALPLALPG | |
| SCHEMBL14308019 | 0.69 | ALDH1A1 (0.43) | ALDH1A1MAPTHTTKDM4EKMT2A | |
| SCHEMBL6327081 | 0.68 | CHRM2 (0.64) | ALDH1A1MAPTHTTALPLALPG | |
| SCHEMBL6122964 | 0.68 | TSHR (0.53) | ALDH1A1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL6122960 | 0.68 | TSHR (0.53) | ALDH1A1RAB9ASMN1; SMN2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1386912-B1 | CYCLIC AMIDINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2009-03-18 | — | — | EP | claimed |
| EP-1386912-B1 | CYCLIC AMIDINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2009-03-18 | — | — | EP | disclosed |