Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4333541 | 1.00 | HTT (0.50) | HTTGRM5ALDH1A1TSHRCHRM2 | |
| SCHEMBL4338472 | 0.83 | ALDH1A1 (0.52) | HTTALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL4338476 | 0.83 | ALDH1A1 (0.52) | HTTALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL11742211 | 0.82 | SLC6A3 (0.50) | HTTGRM5ALDH1A1TSHRCHRM2 | |
| SCHEMBL11742215 | 0.82 | SLC6A3 (0.50) | HTTGRM5ALDH1A1TSHRCHRM2 | |
| SCHEMBL11738486 | 0.79 | GRM5 (0.72) | HTTGRM5ALDH1A1TSHRCHRM2 | |
| SCHEMBL11738480 | 0.79 | GRM5 (0.72) | HTTGRM5ALDH1A1TSHRCHRM2 | |
| SCHEMBL8326096 | 0.79 | L3MBTL1 (0.52) | HTTGRM5ALDH1A1TSHRKDM4E | |
| SCHEMBL8326098 | 0.79 | L3MBTL1 (0.52) | HTTGRM5ALDH1A1TSHRKDM4E | |
| SCHEMBL10418997 | 0.75 | HTT (0.63) | HTTALDH1A1TSHRSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1386912-B1 | CYCLIC AMIDINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2009-03-18 | — | — | EP | claimed |
| EP-1386912-B1 | CYCLIC AMIDINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2009-03-18 | — | — | EP | disclosed |