Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR1 | Q9GZQ6 | 4/20 | 0.50 |
| ▸ | NPFFR2 | Q9Y5X5 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4338712 | 0.87 | MAPT (0.51) | ALDH1A1SMN1; SMN2SLC9A1GAAMAPT | |
| SCHEMBL4330988 | 0.85 | NPFFR1 (0.53) | NPFFR1NPFFR2ALDH1A1SLC9A1MAPT | |
| SCHEMBL4324316 | 0.83 | MAPT (0.38) | ALDH1A1SLC9A1GAAMAPTLMNA | |
| SCHEMBL4329325 | 0.83 | SLC9A1 (0.36) | NPFFR1NPFFR2ALDH1A1SMN1; SMN2SLC9A1 | |
| SCHEMBL4464604 | 0.83 | TP53 (0.38) | ALDH1A1SLC9A1GAAMAPTLMNA | |
| SCHEMBL4331899 | 0.81 | LMNA (0.37) | ALDH1A1SMN1; SMN2SLC9A1MAPTLMNA | |
| SCHEMBL4322273 | 0.80 | MAPT (0.38) | ALDH1A1SMN1; SMN2SLC9A1MAPTLMNA | |
| SCHEMBL4451555 | 0.78 | KDM4E (0.50) | ALDH1A1SLC9A1GAAMAPTLMNA | |
| SCHEMBL4338698 | 0.74 | HKDC1 (0.58) | NPFFR1NPFFR2ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL4338706 | 0.74 | HKDC1 (0.58) | NPFFR1NPFFR2ALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090285849-A1 | Thiosemicarbazones as anti-virals and immunopotentiators | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2009-11-19 | — | — | US | disclosed |
| US-7521062-B2 | Thiosemicarbazones as anti-virals and immunopotentiators | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2009-04-21 | — | — | US | disclosed |
| US-20050069555-A1 | Thiosemicarbazones as anti-virals and immunopotentiators | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090285849-A1 | Thiosemicarbazones as anti-virals and immunopotentiators | MAVS, IRF3, HAVCR2 | NPFFR1 3442/4885NPFFR2 3944/4885ALDH1A1 1459/4885 |
| US-20050069555-A1 | Thiosemicarbazones as anti-virals and immunopotentiators | MAVS, IRF3, HAVCR2 | NPFFR1 2997/4885NPFFR2 3590/4885ALDH1A1 1173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.