Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 4/20 | 0.46 |
| ▸ | INPPL1 | O15357 | 6/20 | 0.41 |
| ▸ | INPP5A | Q14642 | 5/20 | 0.41 |
| ▸ | INPP5B | P32019 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10915218 | 0.88 | HTT (0.52) | HTTMAPTKDM4EGAATP53 | |
| SCHEMBL7534018 | 0.84 | MAPT (0.58) | HTTMAPTKDM4EGAATP53 | |
| Menadiol Diphosphoric Acid SCHEMBL515181 | 0.82 | HTT (0.51) | HTTMAPTKDM4EGAATP53 | |
| Vitamin K3H2 SCHEMBL27560223 | 0.76 | HTT (0.78) | HTTMAPTKDM4EGAATP53 | |
| SCHEMBL9812714 | 0.75 | KDM4E (0.64) | HTTMAPTKDM4EGAATP53 | |
| Vitamin K3H2 SCHEMBL9223417 | 0.75 | HTT (0.70) | HTTMAPTKDM4EGAATP53 | |
| Vitamin K3H2 SCHEMBL987810 | 0.75 | HTT (0.75) | HTTMAPTKDM4EGAATP53 | |
| SCHEMBL25297948 | 0.74 | SRC (0.53) | HTTMAPTKDM4EGAATP53 | |
| Vitamin K3H2 SCHEMBL515182 | 0.74 | HTT (0.81) | HTTMAPTKDM4EGAATP53 | |
| SCHEMBL18327129 | 0.74 | KDM4E (0.62) | HTTMAPTKDM4EGAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10987501-B2 | Cell impregnated sleeve for paracrine and other factor production | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-04-27 | — | — | US | disclosed |
| US-10940088-B1 | Method of preparing low dose pharmaceutical formulations | KING SAUD UNIVERSITY (SA) | 2021-03-09 | — | — | US | disclosed |
| US-20200147358-A1 | CELL IMPREGNATED SLEEVE FOR PARACRINE AND OTHER FACTOR PRODUCTION | UNIV JOHNS HOPKINS (US) | 2020-05-14 | — | — | US | disclosed |
| US-10561830-B2 | Cell impregnated sleeve for paracrine and other factor production | THE JOHNS HOPKINS UNIVERSITY (US) | 2020-02-18 | — | — | US | disclosed |
| US-20160235956-A1 | CELL IMPREGNATED SLEEVE FOR PARACRINE AND OTHER FACTOR PRODUCTION | THE JOHNS HOPKINS UNIVERSITY | 2016-08-18 | — | — | US | disclosed |
| WO-2015054183-A1 | CELL IMPREGNATED SLEEVE FOR PARACRINE AND OTHER FACTOR PRODUCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-04-16 | — | — | WO | disclosed |
| US-20140364368-A1 | STIMULUS RESPONSIVE NANOCOMPLEXES AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-12-11 | — | — | US | disclosed |
| WO-2014197816-A1 | STIMULUS RESPONSIVE NANOCOMPLEXES AND METHODS OF USE THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-12-11 | — | — | WO | disclosed |
| US-8486374-B2 | Alcohol-free drug or cosmetics carrier mixture of water, hydrophobic solvent, surfactant and gelling agent; oil in water emulsions | FOAMIX LTD. (IL) | 2013-07-16 | — | — | US | disclosed |
| US-7605179-B2 | Napthoquinone derivatives as inhibitors of tau aggregation for the treatment of alzheimer's and related neurodegenerative disorders | WISTA LABORATORIES LTD. (SG) | 2009-10-20 | — | — | US | disclosed |
| US-20080292560-A1 | SILICONE IN GLYCOL PHARMACEUTICAL AND COSMETIC COMPOSITIONS WITH ACCOMMODATING AGENT | FOAMIX PHARMACEUTICALS LTD. (IL) | 2008-11-27 | — | — | US | disclosed |
| US-20080206161-A1 | QUIESCENT FOAMABLE COMPOSITIONS, STEROIDS, KITS AND USES THEREOF | FOAMIX PHARMACEUTICALS LTD. (IL) | 2008-08-28 | — | — | US | disclosed |
| US-20080069779-A1 | Foamable vehicle and vitamin and flavonoid pharmaceutical compositions thereof | FOAMIX LTD. (IL) | 2008-03-20 | — | — | US | disclosed |
| EP-1408952-B1 | NAPTHOQUINONE DERIVATIVES AS INHIBITORS OF TAU AGGREGATION FOR THE TREATMENT OF ALZHEIMER'S AND RELATED NEURODEGENERATIVE DISORDERS | WISTA LAB LTD (SG) | 2007-05-02 | — | — | EP | disclosed |
| US-20050107472-A1 | Napthoquinone derivatives as inhibitors of tau aggregation for the treatment of alzheimer's and related neurodegenerative disorders | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) | 2005-05-19 | — | — | US | disclosed |
| EP-1408952-A1 | NAPTHOQUINONE DERIVATIVES AS INHIBITORS OF TAU AGGREGATION FOR THE TREATMENT OF ALZHEIMER'S AND RELATED NEURODEGENERATIVE DISORDERS | The University Court of The University of Aberdeen (GB) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003007933-A1 | NAPTHOQUINONE DERIVATIVES AS INHIBITORS OF TAU AGGREGATION FOR THE TREATMENT OF ALZHEIMER'S AND RELATED NEURODEGENERATIVE DISORDERS | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) | 2003-01-30 | — | — | WO | disclosed |
| EP-0182765-B1 | ELECTROCHEMICAL CONTROLLED RELEASE DRUG DELIVERY SYSTEM | THE REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1992-08-26 | — | — | EP | disclosed |
| EP-0182765-A2 | Electrochemical controlled release drug delivery system | THE REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1986-05-28 | — | — | EP | disclosed |
| US-4585652-A | REDOX SITES ON CHARGED POLYMER | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1986-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080206161-A1 | QUIESCENT FOAMABLE COMPOSITIONS, STEROIDS, KITS AND USES THEREOF | NR5A1, CYP17A1, LIPA | HTT 3149/4885MAPT 4587/4885KDM4E 362/4885 |
| US-20080292560-A1 | SILICONE IN GLYCOL PHARMACEUTICAL AND COSMETIC COMPOSITIONS WITH ACCOMMODATING AGENT | SSTR2, SSTR3, LPXN | HTT 498/4885MAPT 1240/4885KDM4E 4521/4885 |
| US-20080069779-A1 | Foamable vehicle and vitamin and flavonoid pharmaceutical compositions thereof | PROC, VKORC1, TTPA | HTT 188/4885MAPT 1551/4885KDM4E 3332/4885 |
| US-20050107472-A1 | Napthoquinone derivatives as inhibitors of tau aggregation for the treatment of alzheimer's and related neurodegenerative disorders | MAPT, PSEN1, PSEN2 | HTT 45/4885MAPT 1/4885KDM4E 3803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.