Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2000188 | 0.79 | NR1H4 (0.48) | ALDH1A1POLBNR1H4LMNATSHR | |
| SCHEMBL4336583 | 0.78 | KMT2A (0.41) | ALDH1A1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL17839763 | 0.76 | KMT2A (0.41) | ALDH1A1POLBNR1H4KMT2AMEN1 | |
| SCHEMBL2003475 | 0.74 | KMT2A (0.39) | ALDH1A1POLBNR1H4KMT2AMEN1 | |
| SCHEMBL4952726 | 0.72 | LMNA (0.42) | NR1H4KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL4953612 | 0.72 | GHSR (0.37) | NR1H4RAB9ANPC1MAPTLMNA | |
| SCHEMBL4345731 | 0.68 | NPC1 (0.30) | RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4339369 | 0.68 | NR1H4 (0.36) | ALDH1A1NR1H4KMT2AMEN1RAB9A | |
| SCHEMBL17839920 | 0.66 | KMT2A (0.39) | ALDH1A1POLBNR1H4KMT2AMEN1 | |
| SCHEMBL28324415 | 0.66 | KMT2A (0.39) | ALDH1A1POLBNR1H4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079307-A2 | FARNESOID X RECEPTOR AGONISTS | SmithKline Beecham Corporation (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008051942-A2 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-05-02 | — | — | WO | disclosed |