Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SOD1 | P00441 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CFTR | P13569 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4952726 | 0.82 | LMNA (0.42) | NR1H4GHSRGPBAR1MEN1KMT2A | |
| SCHEMBL4953612 | 0.82 | GHSR (0.37) | NR1H4GHSRGPBAR1NPC1RAB9A | |
| SCHEMBL2002072 | 0.79 | NR1H4 (0.51) | NR1H4 | |
| SCHEMBL4345558 | 0.78 | POLB (0.43) | GHSRGPBAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL3638644 | 0.75 | GHSR (0.50) | NR1H4GHSRGPBAR1KMT2ANPC1 | |
| SCHEMBL4339510 | 0.68 | ALDH1A1 (0.36) | NR1H4MEN1KMT2ANPC1RAB9A | |
| SCHEMBL4335252 | 0.67 | GHSR (0.50) | NR1H4GHSRGPBAR1MEN1KMT2A | |
| SCHEMBL12168922 | 0.66 | GHSR (0.49) | NR1H4GHSRGPBAR1ALDH1A1LMNA | |
| SCHEMBL4330251 | 0.65 | GHSR (0.42) | NR1H4GHSRGPBAR1NPC1ALDH1A1 | |
| SCHEMBL320714 | 0.65 | TAAR1 (0.41) | MEN1KMT2ACFTRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079307-A2 | FARNESOID X RECEPTOR AGONISTS | SmithKline Beecham Corporation (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008051942-A2 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-05-02 | — | — | WO | disclosed |