Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002126 | 0.81 | NR1H4 (0.44) | KMT2AMEN1MAPTTDP1L3MBTL1 | |
| SCHEMBL4339510 | 0.78 | ALDH1A1 (0.36) | KMT2AMEN1MAPTGAASMN1; SMN2 | |
| SCHEMBL4336590 | 0.77 | LMNA (0.44) | MAPTL3MBTL1GAAMAPK1SMN1; SMN2 | |
| SCHEMBL4946160 | 0.75 | POLB (0.45) | KMT2AMEN1MAPTL3MBTL1GAA | |
| SCHEMBL4951120 | 0.75 | POLB (0.45) | KMT2AMEN1MAPTL3MBTL1GAA | |
| SCHEMBL4337377 | 0.75 | LMNA (0.39) | MAPTL3MBTL1GAAMAPK1SMN1; SMN2 | |
| SCHEMBL4348580 | 0.74 | LMNA (0.42) | MAPTL3MBTL1GAAMAPK1SMN1; SMN2 | |
| SCHEMBL4345558 | 0.73 | POLB (0.43) | KMT2AMEN1MAPTL3MBTL1GAA | |
| SCHEMBL4339344 | 0.72 | NR1H4 (0.45) | KMT2AMEN1 | |
| SCHEMBL13283814 | 0.72 | HTT (0.47) | KMT2AMEN1MAPTL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079307-A2 | FARNESOID X RECEPTOR AGONISTS | SmithKline Beecham Corporation (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008051942-A2 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-05-02 | — | — | WO | disclosed |