Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.56 |
| ▸ | HTR3B | O95264 | 3/20 | 0.56 |
| ▸ | HTR3A | P46098 | 3/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.56 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.54 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | PNMT | P11086 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4322049 | 1.00 | HTR3E (0.56) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL4327982 | 0.84 | ALDH1A1 (0.51) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL4320320 | 0.84 | ALDH1A1 (0.51) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL3917563 | 0.81 | CES1 (0.52) | CTBP2ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3917561 | 0.81 | CES1 (0.52) | CTBP2ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4320859 | 0.81 | HCAR2 (0.49) | HCAR2TAAR1MAPK8MEN1KMT2A | |
| SCHEMBL4320854 | 0.81 | HCAR2 (0.49) | HCAR2TAAR1MAPK8MEN1KMT2A | |
| SCHEMBL4320314 | 0.81 | HCAR2 (0.49) | HCAR2TAAR1MAPK8IDO1PARP1 | |
| SCHEMBL4317706 | 0.80 | PDPK1 (0.47) | CTBP2ALDH1A1TAAR1PIK3CAMEN1 | |
| SCHEMBL4317702 | 0.80 | PDPK1 (0.47) | CTBP2ALDH1A1TAAR1PIK3CAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009146696-A1 | USE OF INDOLE-3-CARBOXYLIC ESTERS FOR INHIBITING MICROSOMAL PROSTAGLANDIN E2 SYNTHASE | Universität Tübingen (DE) | 2009-12-10 | — | — | WO | disclosed |