Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | THRA | P10827 | 1/20 | 0.66 |
| ▸ | THRB | P10828 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | BCHE | P06276 | 5/20 | 0.61 |
| ▸ | ACHE | P22303 | 3/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | SCN1A | P35498 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491797 | 0.89 | L3MBTL1 (0.69) | L3MBTL1GAABCHEACHEMAOB | |
| SCHEMBL1092185 | 0.88 | L3MBTL1 (0.85) | L3MBTL1GAATP53TSHRLMNA | |
| SCHEMBL2472164 | 0.88 | TP53 (0.71) | THRATHRBBCHEACHETP53 | |
| SCHEMBL321662 | 0.86 | THRA (0.64) | THRATHRBGAABCHEACHE | |
| Hydrochloric Acid SCHEMBL3853408 | 0.86 | TP53 (0.69) | THRATHRBBCHEACHETP53 | |
| SCHEMBL15537107 | 0.86 | THRA (0.64) | THRATHRBGAABCHEACHE | |
| Hydrochloric Acid SCHEMBL15049975 | 0.86 | TP53 (0.69) | THRATHRBBCHEACHETP53 | |
| SCHEMBL1470028 | 0.85 | L3MBTL1 (0.85) | L3MBTL1THRATHRBGAATP53 | |
| SCHEMBL2472562 | 0.85 | MAPT (0.66) | THRATHRBGAABCHEACHE | |
| Hydrochloric Acid SCHEMBL284154 | 0.85 | THRA (0.63) | THRATHRBGAABCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9512097-B2 | Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives | LEK PHARMACEUTICALS D.D. (SI) | 2016-12-06 | — | — | US | disclosed |
| US-9512097-B2 | Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives | LEK PHARMACEUTICALS D.D. (SI) | 2016-12-06 | — | — | US | disclosed |
| US-8748636-B2 | Process for preparing benzofuran derivatives substituted at position 5 | SANOFI (FR) | 2014-06-10 | — | — | US | disclosed |
| US-8674121-B2 | Process for the production of benzofurans | SANOFI (FR) | 2014-03-18 | — | — | US | disclosed |
| EP-2435398-B1 | PROCESS FOR THE PRODUCTION OF BENZOFURANS | SANOFI SA (FR) | 2014-01-22 | — | — | EP | disclosed |
| US-20130317100-A1 | PROCESS FOR THE PREPARATION OF 3-AROYL-5-AMINOBENZOFURAN DERIVATIVES | LEK PHARMACEUTICALS D.D. (SI) | 2013-11-28 | — | — | US | disclosed |
| EP-2638024-A1 | PROCESS FOR THE PREPARATION OF 3-AROYL-5-AMINOBENZOFURAN DERIVATIVES | LEK Pharmaceuticals d.d. (SI) | 2013-09-18 | — | — | EP | disclosed |
| US-20130165674-A1 | PROCESS FOR PREPARING BENZOFURAN DERIVATIVES SUBSTITUTED AT POSITION 5 | SANOFI (FR) | 2013-06-27 | — | — | US | disclosed |
| EP-2595977-A1 | PROCESS FOR PREPARING BENZOFURAN DERIVATIVES SUBSTITUTED AT POSITION 5 | SANOFI (FR) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012062918-A1 | PROCESS FOR THE PREPARATION OF 3-AROYL-5-AMINOBENZOFURAN DERIVATIVES | LEK PHARMACEUTICALS D.D. (SI) | 2012-05-18 | — | — | WO | disclosed |
| WO-2012062918-A1 | PROCESS FOR THE PREPARATION OF 3-AROYL-5-AMINOBENZOFURAN DERIVATIVES | LEK PHARMACEUTICALS D.D. (SI) | 2012-05-18 | — | — | WO | disclosed |
| EP-2452938-A1 | Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives | LEK Pharmaceuticals d.d. (SI) | 2012-05-16 | — | — | EP | disclosed |
| EP-2452938-A1 | Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives | LEK Pharmaceuticals d.d. (SI) | 2012-05-16 | — | — | EP | disclosed |
| US-20120065411-A1 | PROCESS FOR THE PRODUCTION OF BENZOFURANS | SANOFI (FR) | 2012-03-15 | — | — | US | disclosed |
| WO-2012010802-A1 | PROCESS FOR PREPARING BENZOFURAN DERIVATIVES SUBSTITUTED AT POSITION 5 | SANOFI (FR) | 2012-01-26 | — | — | WO | disclosed |
| US-20110178314-A1 | PROCESS FOR PREPARING 2-ALKYL-3-AROYL-5-NITRO-BENZOFURANS | LONZA AG (CH) | 2011-07-21 | — | — | US | disclosed |
| EP-2344467-A1 | PROCESS FOR PREPARING 2-ALKYL-3-AROYL-5-NITRO-BENZOFURANS | Lonza Ltd. (CH) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010136500-A1 | PROCESS FOR THE PRODUCTION OF BENZOFURANS | SANOFI-AVENTIS (FR) | 2010-12-02 | — | — | WO | disclosed |
| EP-2246341-A1 | Process for preparing 2-Alkyl-3-aroyl-5-nitro-benzofurans | Lonza Ltd. (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010040261-A1 | PROCESS FOR PREPARING 2-ALKYL-3-AROYL-5-NITRO-BENZOFURANS | LONZA LTD (CH) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165674-A1 | PROCESS FOR PREPARING BENZOFURAN DERIVATIVES SUBSTITUTED AT POSITION 5 | DHPS, SDHA, CYP2F1 | L3MBTL1 4375/4885THRA 3592/4885THRB 3390/4885 |
| US-20130317100-A1 | PROCESS FOR THE PREPARATION OF 3-AROYL-5-AMINOBENZOFURAN DERIVATIVES | CYP3A5, CYP4F3, CYP3A4 | L3MBTL1 4354/4885THRA 3854/4885THRB 3183/4885 |
| US-20120065411-A1 | PROCESS FOR THE PRODUCTION OF BENZOFURANS | CYP2F1, CYP2B6, CYP4F2 | L3MBTL1 3348/4885THRA 3015/4885THRB 3589/4885 |
| US-20110178314-A1 | PROCESS FOR PREPARING 2-ALKYL-3-AROYL-5-NITRO-BENZOFURANS | NR4A3, CBR3, NR4A1 | L3MBTL1 3448/4885THRA 1857/4885THRB 2327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.