⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL83079 | 0.73 | MGLL (0.42) | — | |
| SCHEMBL709406 | 0.73 | MGLL (0.42) | — | |
| SCHEMBL16256331 | 0.69 | — | — | |
| SCHEMBL24003668 | 0.69 | — | — | |
| SCHEMBL5577325 | 0.67 | MGLL (0.43) | — | |
| SCHEMBL29360862 | 0.66 | MGLL (0.33) | — | |
| SCHEMBL19954787 | 0.65 | MGLL (0.35) | — | |
| SCHEMBL23811171 | 0.64 | XPO1 (0.32) | — | |
| SCHEMBL19057261 | 0.63 | MGLL (0.46) | — | |
| SCHEMBL19413456 | 0.63 | MGLL (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11377473-B2 | Albumin-binding prodrugs of auristatin E derivatives | CENTURION BIOPHARMA CORPORATION (US) | 2022-07-05 | — | — | US | disclosed |
| US-11129910-B2 | Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2021-09-28 | — | — | US | disclosed |
| US-20200385421-A1 | ALBUMIN-BINDING PRODRUGS OF AURISTATIN E DERIVATIVES | LADRX CORPORATION | 2020-12-10 | — | — | US | disclosed |
| US-20200215206-A1 | SPECIFIC CONJUGATION LINKERS, SPECIFIC IMMUNOCONJUGATES THEREOF, METHODS OF MAKING AND USES SUCH CONJUGATES THEREOF | SUZHOU M-CONJ BIOTECH CO., LTD. (CN) | 2020-07-09 | — | — | US | disclosed |
| US-10639381-B2 | Trioxacarcins, trioxacarcin#antibody conjugates, and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2020-05-05 | — | — | US | disclosed |
| US-10414826-B2 | Monomethylvaline compounds capable of conjugation to ligands | SEATTLE GENETICS, INC. (US) | 2019-09-17 | — | — | US | disclosed |
| US-20180221504-A1 | TRIOXACARCINS, TRIOXACARCIN-ANTIBODY CONJUGATES, AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-08-09 | — | — | US | disclosed |
| US-20180127512-A1 | MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS | SEAGEN INC. | 2018-05-10 | — | — | US | disclosed |
| EP-2820013-A1 | LIVER X RECEPTOR (LXR) MODULATORS FOR THE TREATMENT OF DERMAL DISEASES, DISORDERS AND CONDITIONS | Alexar Therapeutics, Inc. (US) | 2015-01-07 | — | — | EP | disclosed |
| EP-2797875-A1 | CINNAMIC ACID HYDROXYAMIDES AS INHIBITORS OF HISTONE DEACETYLASE 8 | Pharmacyclics, Inc. (US) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013059666-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2013-04-25 | — | — | WO | disclosed |
| EP-2582374-A2 | METHODS FOR TREATING NEUROLOGICAL CONDITIONS | Afraxis, Inc. (US) | 2013-04-24 | — | — | EP | disclosed |
| WO-2013003629-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF BONE RESORPTION | PHARMACYCLICS, INC. (US) | 2013-01-03 | — | — | WO | disclosed |
| WO-2011159945-A2 | METHODS FOR TREATING NEUROLOGICAL CONDITIONS | AFRAXIS, INC. (US) | 2011-12-22 | — | — | WO | disclosed |
| CN-101861362-A | Two chromophoric group carbonyls or heterocyclic dye, contain this dyestuff dye composite, adopt this dyestuff that keratin material is carried out painted method | OREAL | 2010-10-13 | — | — | CN | disclosed |
| CN-101684204-A | Hemicyanin styryl thiol/disulfide dye, dye composition comprising this dye, process for lightening keratin materials using this dye | OREAL | 2010-03-31 | — | — | CN | disclosed |
| US-7598092-B2 | Methods, devices, systems and computer program products for stochastic, competitive, force-based analyte detection | TOONE ERIC | 2009-10-06 | — | — | US | disclosed |
| WO-2008051314-A2 | METHODS, DEVICES, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR STOCHASTIC, COMPETITIVE, FORCE-BASED ANALYTE DETECTION | DUKE UNIVERSITY (US) | 2008-05-02 | — | — | WO | disclosed |
| US-20080090259-A1 | METHODS, DEVICES, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR STOCHASTIC, COMPETITIVE, FORCE-BASED ANALYTE DETECTION | TOONE ERIC | 2008-04-17 | — | — | US | disclosed |
| US-20070134762-A1 | Immunogenic peptide carrier conjugates and methods of producing same | WYETH LLC | 2007-06-14 | — | — | US | disclosed |