⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL83079 | 0.73 | MGLL (0.42) | — | |
| SCHEMBL709406 | 0.73 | MGLL (0.42) | — | |
| SCHEMBL19848642 | 0.69 | MGLL (0.39) | — | |
| SCHEMBL19057261 | 0.69 | MGLL (0.46) | — | |
| SCHEMBL24003668 | 0.69 | — | — | |
| SCHEMBL4340966 | 0.69 | — | — | |
| SCHEMBL5577325 | 0.67 | MGLL (0.43) | — | |
| SCHEMBL20621537 | 0.63 | MGLL (0.52) | — | |
| SCHEMBL11749637 | 0.63 | ALDH1A1 (0.47) | — | |
| SCHEMBL2267922 | 0.63 | GSK3A (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111978235-A | Preparation method of 3-amino-4-methylmercaptomaleimide compound | 温州医科大学 | 2020-11-24 | — | — | CN | claimed |
| WO-2024129628-A1 | AURISTATIN LINKER-PAYLOADS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | MERCK SHARP & DOHME LLC (US) | 2024-06-20 | — | — | WO | disclosed |
| US-20220332687-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | SANOFI (FR) | 2022-10-20 | — | — | US | disclosed |
| US-11384104-B2 | Delivery systems for controlled drug release | CENTURION BIOPHARMA CORPORATION (US) | 2022-07-12 | — | — | US | disclosed |
| US-20210353765-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | AVVINITY THERAPEUTICS LIMITED (GB/GB) (GB) | 2021-11-18 | — | — | US | disclosed |
| EP-3889154-A1 | HETEROCYCLIC COMPOUND INTERMEDIATE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Wuhan LL Science And Technology Development Co., Ltd. (CN) | 2021-10-06 | — | — | EP | disclosed |
| WO-2021195183-A1 | COMPOSITIONS AND METHODS FOR INHIBITING PROTEIN EMBRYONIC ECTODERM DEVELOPMENT ACTIVITY AND TREATING DISEASE | EXO THERAPEUTICS, INC. (US) | 2021-09-30 | — | — | WO | disclosed |
| WO-2020236841-A2 | ANTIBODY DRUG CONJUGATES HAVING LINKERS COMPRISING HYDROPHILIC GROUPS | NOVARTIS AG (CH) | 2020-11-26 | — | — | WO | disclosed |
| CN-111978235-A | Preparation method of 3-amino-4-methylmercaptomaleimide compound | 温州医科大学 | 2020-11-24 | — | — | CN | disclosed |
| CN-111978235-A | Preparation method of 3-amino-4-methylmercaptomaleimide compound | 温州医科大学 | 2020-11-24 | — | — | CN | disclosed |
| US-20180059541-A1 | CLICK-CHEMISTRY COMPATIBLE STRUCTURES, CLICK-CHEMISTRY FUNCTIONALIZED STRUCTURES, AND MATERIALS AND METHODS FOR MAKING THE SAME | U.S. DEPARTMENT OF ENERGY | 2018-03-01 | — | — | US | disclosed |
| US-20180051031-A1 | SECO-CYCLOPROPAPYRROLOINDOLE COMPOUNDS, ANTIBODY-DRUG CONJUGATES THEREOF, AND METHODS OF MAKING AND USE | THE SCRIPPS RESEARCH INSTITUTE | 2018-02-22 | — | — | US | disclosed |
| US-20180022713-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2018-01-25 | — | — | US | disclosed |
| US-9717668-B2 | Methods for treating relaxed hair | LIQWD, INC. (US) | 2017-08-01 | — | — | US | disclosed |
| US-9695132-B2 | Heteroaryl compounds and uses thereof | CELGENE CAR LLC (BM) | 2017-07-04 | — | — | US | disclosed |
| US-9676785-B2 | HCV protease inhibitors and uses thereof | CELGENE CAR LLC (BM) | 2017-06-13 | — | — | US | disclosed |
| US-9493394-B2 | Photoaligning materials | ROLIC AG (CH) | 2016-11-15 | — | — | US | disclosed |
| US-9334366-B2 | Photoaligning materials | ROLIC AG (CH) | 2016-05-10 | — | — | US | disclosed |
| US-20160062020-A1 | RETARDATION FILM, AND CIRCULARLY POLARIZING PLATE AND IMAGE DISPLAY DEVICE USING THE RETARDATION FILM | Konica Minolta, Inc. (JP) | 2016-03-03 | — | — | US | disclosed |
| US-20140342086-A1 | PHOTOALIGNING MATERIALS | ROLIC AG (CH) | 2014-11-20 | — | — | US | disclosed |