Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GHSR | Q92847 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4951120 | 0.83 | POLB (0.45) | POLBGHSRALDH1A1LMNAHPGD | |
| SCHEMBL4946160 | 0.83 | POLB (0.45) | POLBGHSRALDH1A1LMNAHPGD | |
| SCHEMBL2007489 | 0.81 | NR1H4 (0.47) | POLBGHSRALDH1A1LMNAHPGD | |
| SCHEMBL4339369 | 0.78 | NR1H4 (0.36) | GHSRALDH1A1LMNAHPGDALOX5 | |
| SCHEMBL4336590 | 0.75 | LMNA (0.44) | POLBGHSRALDH1A1LMNAGAA | |
| SCHEMBL4336583 | 0.73 | KMT2A (0.41) | GHSRALDH1A1LMNAGAAMAPT | |
| SCHEMBL4348580 | 0.73 | LMNA (0.42) | POLBGHSRALDH1A1LMNAGAA | |
| SCHEMBL4337377 | 0.71 | LMNA (0.39) | GHSRALDH1A1LMNAGAAMAPT | |
| SCHEMBL18605355 | 0.69 | LMNA (0.43) | POLBALDH1A1LMNAGAAMAPT | |
| SCHEMBL13283814 | 0.68 | HTT (0.47) | POLBALDH1A1LMNAHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079307-A2 | FARNESOID X RECEPTOR AGONISTS | SmithKline Beecham Corporation (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008051942-A2 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-05-02 | — | — | WO | disclosed |