Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4336590 | 0.83 | LMNA (0.44) | LMNAALDH1A1HTTL3MBTL1MAPK1 | |
| SCHEMBL4348580 | 0.80 | LMNA (0.42) | LMNAALDH1A1HTTL3MBTL1MAPK1 | |
| SCHEMBL18605355 | 0.76 | LMNA (0.43) | LMNAALDH1A1HTTL3MBTL1MAPK1 | |
| SCHEMBL4336583 | 0.75 | KMT2A (0.41) | LMNAALDH1A1HTTL3MBTL1MAPK1 | |
| SCHEMBL13283814 | 0.75 | HTT (0.47) | LMNAALDH1A1HTTL3MBTL1HSD17B10 | |
| SCHEMBL28804378 | 0.71 | ALDH1A1 (0.43) | LMNAALDH1A1HTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL4345558 | 0.71 | POLB (0.43) | LMNAALDH1A1L3MBTL1MAPTGHSR | |
| SCHEMBL4951120 | 0.71 | POLB (0.45) | LMNAALDH1A1HTTL3MBTL1MAPK1 | |
| SCHEMBL4946160 | 0.71 | POLB (0.45) | LMNAALDH1A1HTTL3MBTL1MAPK1 | |
| SCHEMBL18605168 | 0.71 | ALDH1A1 (0.42) | LMNAALDH1A1HTTL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079307-A2 | FARNESOID X RECEPTOR AGONISTS | SmithKline Beecham Corporation (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008051942-A2 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-05-02 | — | — | WO | disclosed |