Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2301632 | 0.84 | HTR2A (0.33) | — | |
| SCHEMBL2303091 | 0.82 | NPC1 (0.51) | NPC1RAB9AABL1BCRSIGMAR1 | |
| SCHEMBL28645698 | 0.70 | XDH (0.59) | ABL1BCRXDHLMNANPSR1 | |
| SCHEMBL29863560 | 0.70 | XDH (0.59) | ABL1BCRXDHLMNANPSR1 | |
| SCHEMBL11595465 | 0.70 | SIGMAR1 (0.43) | SIGMAR1XDHLMNA | |
| SCHEMBL11596169 | 0.68 | CYP1A2 (0.55) | ABL1BCRSIGMAR1XDHLMNA | |
| SCHEMBL13061230 | 0.66 | NPC1 (0.56) | NPC1RAB9AABL1BCRSIGMAR1 | |
| SCHEMBL14635580 | 0.66 | SIGMAR1 (0.71) | SIGMAR1 | |
| SCHEMBL14636547 | 0.66 | SIGMAR1 (0.71) | SIGMAR1 | |
| SCHEMBL24121794 | 0.65 | SIGMAR1 (0.39) | SIGMAR1LMNANPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024360-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES | Cephalon, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2008063232-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES | CEPHALON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |