Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 13/20 | 0.38 |
| ▸ | MAOA | P21397 | 8/20 | 0.38 |
| ▸ | KDM1A | O60341 | 5/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4811682 | 0.79 | MAOB (0.38) | MAOBMAOA | |
| SCHEMBL5479147 | 0.79 | MAOB (0.38) | MAOBMAOAKDM1AOPRM1OPRL1 | |
| SCHEMBL1560264 | 0.78 | HTR2C (0.41) | OPRM1OPRL1 | |
| SCHEMBL6230490 | 0.76 | MAOA (0.48) | MAOBMAOAKDM1A | |
| SCHEMBL8072323 | 0.75 | OPRL1 (0.35) | MAOBMAOAKDM1AOPRM1OPRL1 | |
| SCHEMBL11126717 | 0.75 | LMNA (0.36) | MAOBMAOAKDM1AOPRM1OPRL1 | |
| SCHEMBL4808314 | 0.74 | MAOB (0.35) | MAOBOPRM1 | |
| SCHEMBL11133978 | 0.73 | HTR2C (0.36) | MAOBMAOAOPRM1 | |
| SCHEMBL13224854 | 0.73 | PTGS2 (0.36) | MAOBMAOAOPRM1 | |
| SCHEMBL4402453 | 0.73 | PTGS2 (0.36) | MAOBMAOAOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094677-A1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO-DEGENERATIVE DISEASES | NV Remynd (BE) | 2009-09-02 | — | — | EP | disclosed |
| EP-1981504-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV Remynd (BE) | 2008-10-22 | — | — | EP | disclosed |
| EP-1960376-A1 | OXADIAZOLE DERIVATIVES WITH CRTH2 RECEPTOR ACTIVITY | 7TM Pharma A/S (DK) | 2008-08-27 | — | — | EP | disclosed |
| WO-2008061781-A1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO-DEGENERATIVE DISEASES | NV REMYND (BE) | 2008-05-29 | — | — | WO | disclosed |
| WO-2007090617-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV REMYND (BE) | 2007-08-16 | — | — | WO | disclosed |
| WO-2007062773-A1 | OXADIAZOLE DERIVATIVES WITH CRTH2 RECEPTOR ACTIVITY | 7TM PHARMA A/S (DK) | 2007-06-07 | — | — | WO | disclosed |