SCHEMBL4348236

SCHEMBL4348236

CC(O)C[C@]1(n2ccc(=O)[nH]c2=O)C[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O1

nearest known ligand 0.54

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
P2RY6 Q15077 12/20 0.54
P2RY2 P41231 12/20 0.52
P2RY4 P51582 8/20 0.52
POLA1 P09884 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8436036 0.90 P2RY6 (0.58) P2RY6P2RY2P2RY4POLA1
SCHEMBL28293726 0.89 P2RY6 (0.58) P2RY6P2RY2P2RY4POLA1
SCHEMBL8441389 0.88 P2RY6 (0.56) P2RY6P2RY2P2RY4POLA1
SCHEMBL8437011 0.86 P2RY6 (0.54) P2RY6P2RY2P2RY4POLA1
SCHEMBL8440658 0.86 P2RY6 (0.54) P2RY6P2RY2P2RY4POLA1
SCHEMBL4619794 0.85 P2RY6 (0.55) P2RY6P2RY2P2RY4POLA1
SCHEMBL8439799 0.85 P2RY6 (0.57) P2RY6P2RY2P2RY4POLA1
SCHEMBL8440615 0.85 P2RY6 (0.53) P2RY6P2RY2P2RY4POLA1
SCHEMBL95680 0.85 P2RY6 (0.54) P2RY6P2RY2P2RY4POLA1
SCHEMBL8441087 0.84 P2RY6 (0.59) P2RY6P2RY2P2RY4POLA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8846893-B2 Non-ionically bound constructs, and compositions and kits comprising domains ENZO BIOCHEM, INC. (US) 2014-09-30 US disclosed
US-8742090-B2 Property effecting and/or property exhibiting compositions for therapeutic and diagnostic uses ENZO BIOCHEM, INC. (US) 2014-06-03 US disclosed
US-8735145-B2 Property effecting and/or property exhibiting compositions for therapeutic and diagnostic uses ENZO BIOCHEM, INC. (US) 2014-05-27 US disclosed
EP-2042606-A1 Novel property effecting and/or property exhibiting compositions for therapeutic and diagnostic use ENZO THERAPEUTICS, INC. (US) 2009-04-01 EP disclosed
US-20080248564-A1 Expression vector comprising ligand conjugates for use and expression of heterologus nucleotide sequences in cells ENZO THERAPEUTICS, INC. (US) 2008-10-09 US disclosed
EP-0779365-B1 Methods to introduce nucleic acid into cells for therapeutic and diagnostic uses ENZO THERAPEUTICS INC (US) 2008-09-17 EP disclosed
US-20080108139-A1 Expression vector comprising nucleotide sequences coding polymerase for use in eukaryotic specific expression of functional heterologous proteins ENZO THERAPEUTICS, INC. (US) 2008-05-08 US disclosed
US-20030104620-A1 Expression vector for expression of heterologous polypeptides and amplification of cell viral resistance; viricides ENZO BIOCHEM, INC. 2003-06-05 US disclosed
US-20030087434-A1 Expression vector for use gene transfer tool in genetic engineering ENZO BIOCHEM, INC. 2003-05-08 US disclosed
US-20010007767-A1 Genetic engineering ENZO BIOCHEM, INC. 2001-07-12 US disclosed
US-20010006816-A1 Dna, rna hybrid ENZO BIOCHEM, INC. 2001-07-05 US disclosed
US-20010006814-A1 Chemical modification ENZO BIOCHEM, INC. 2001-07-05 US disclosed
US-20010006815-A1 Chemical modification ENZO BIOCHEM, INC. 2001-07-05 US disclosed
EP-0779365-A2 Methods to introduce nucleic acid into cells for therapeutic and diagnostic uses ENZO THERAPEUTICS, INC. (US) 1997-06-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030104620-A1 Expression vector for expression of heterologous polypeptides and amplification of cell viral resistance; viricides HAVCR2, RNASE1, RNPEP P2RY6 3094/4885P2RY2 3384/4885P2RY4 3304/4885
US-20010006814-A1 Chemical modification RNASE1, DNASE1L3, DNASE1 P2RY6 823/4885P2RY2 1495/4885P2RY4 1171/4885
US-20080108139-A1 Expression vector comprising nucleotide sequences coding polymerase for use in eukaryotic specific expression of functional heterologous proteins RNGTT, RNASE1, MRPL21 P2RY6 2660/4885P2RY2 3105/4885P2RY4 3450/4885
US-20030087434-A1 Expression vector for use gene transfer tool in genetic engineering RNASE1, GUSB, DCLRE1B P2RY6 4020/4885P2RY2 4685/4885P2RY4 4710/4885
US-20010007767-A1 Genetic engineering DCLRE1B, RNASE1, DNASE1L3 P2RY6 1367/4885P2RY2 2267/4885P2RY4 2337/4885
US-20010006815-A1 Chemical modification RNASE1, DNASE1L3, DNASE1 P2RY6 823/4885P2RY2 1495/4885P2RY4 1171/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.