Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 3/20 | 0.51 |
| ▸ | CASP7 | P55210 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29618363 | 0.92 | CASP7 (0.50) | TYMSCASP7CASP1HSD17B10PBRM1 | |
| SCHEMBL2300153 | 0.92 | CASP7 (0.50) | TYMSCASP7CASP1HSD17B10PBRM1 | |
| SCHEMBL23051659 | 0.83 | PBRM1 (0.47) | TYMSCASP7CASP1HSD17B10PBRM1 | |
| SCHEMBL31591224 | 0.83 | PBRM1 (0.47) | TYMSCASP7CASP1HSD17B10PBRM1 | |
| SCHEMBL460543 | 0.83 | CASP1 (0.57) | TYMSCASP7CASP1HSD17B10PBRM1 | |
| SCHEMBL21772243 | 0.81 | MEN1 (0.49) | TYMSCASP7CASP1HSD17B10HSD17B1 | |
| SCHEMBL15180109 | 0.80 | HSD17B10 (0.50) | TYMSCASP7CASP1HSD17B10PBRM1 | |
| SCHEMBL30957305 | 0.76 | CASP1 (0.50) | CASP7CASP1HSD17B10PBRM1HSD17B1 | |
| SCHEMBL21505155 | 0.76 | CASP1 (0.50) | CASP7CASP1HSD17B10PBRM1HSD17B1 | |
| SCHEMBL1025098 | 0.76 | HSD17B10 (0.50) | TYMSCASP7CASP1HSD17B10PBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220332718-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | GENENTECH, INC. (US) | 2022-10-20 | — | — | US | disclosed |
| CN-108473498-B | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2021-11-02 | — | — | CN | disclosed |
| US-11034698-B2 | Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators | GENENTECH, INC. (US) | 2021-06-15 | — | — | US | disclosed |
| US-11034698-B2 | Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators | GENENTECH, INC. (US) | 2021-06-15 | — | — | US | disclosed |
| US-10988478-B1 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | GENENTECH, INC. (US) | 2021-04-27 | — | — | US | disclosed |
| US-10988478-B1 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | GENENTECH, INC. (US) | 2021-04-27 | — | — | US | disclosed |
| EP-2595966-B1 | SYNTHESIS OF CYCLOPENTAQUINAZOLINES | BTG INT LTD (GB) | 2020-10-28 | — | — | EP | disclosed |
| EP-2595966-B1 | SYNTHESIS OF CYCLOPENTAQUINAZOLINES | BTG INT LTD (GB) | 2020-10-28 | — | — | EP | disclosed |
| CN-111094292-A | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2020-05-01 | — | — | CN | disclosed |
| EP-3642204-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | H. Hoffnabb-La Roche Ag (CH) | 2020-04-29 | — | — | EP | disclosed |
| US-7250511-B2 | Process for the preparation of cyclopenta[g]quinazoline derivatives | BTG INTERNATIONAL LIMITED (GB) | 2007-07-31 | — | — | US | disclosed |
| US-20040266798-A1 | Process for the preparation of cyclopenta[g]quinazoline derivatives | BTG INTERNATIONAL LIMITED (GB) | 2004-12-30 | — | — | US | disclosed |
| EP-1421069-A1 | PROCESS FOR THE PREPARATION OF CYCLOPENTA[G]QUINAZOLINE DERIVATIVES | BTG International Limited (GB) | 2004-05-26 | — | — | EP | disclosed |
| US-RE38103-E1 | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 | MERCK FROSST CANADA & CO. (CA) | 2003-04-29 | — | — | US | disclosed |
| WO-2003020706-A1 | PROCESS FOR THE PREPARATION OF CYCLOPENTA[g]QUINAZOLINE DERIVATIVES | BTG INTERNATIONAL LIMITED (GB) | 2003-03-13 | — | — | WO | disclosed |
| EP-0673366-B1 | 5-METHANESULFONAMIDO-1-INDANONES AS AN INHIBITOR OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC (CA) | 1998-10-14 | — | — | EP | disclosed |
| US-5604260-A | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 | MERCK FROSST CANADA INC. (CA) | 1997-02-18 | — | — | US | disclosed |
| EP-0673366-A1 | 5-METHANESULFONAMIDO-1-INDANONES AS AN INHIBITOR OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC. (CA) | 1995-09-27 | — | — | EP | disclosed |
| US-5409944-A | Enzyme inhibitors, antiinflammatory agent, antiseptic agent | MERCK FROSST CANADA, INC. (CA) | 1995-04-25 | — | — | US | disclosed |
| WO-1994013635-A1 | 5-METHANESULFONAMIDO-1-INDANONES AS AN INHIBITOR OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC. (CA) | 1994-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11034698-B2 | Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators | IRAK4, IRAK1, IRAK2 | TYMS 171/4885CASP7 971/4885CASP1 23/4885 |
| US-20040266798-A1 | Process for the preparation of cyclopenta[g]quinazoline derivatives | COX6A1, MT-ND6, CYP2D6 | TYMS 4471/4885CASP7 1394/4885CASP1 2488/4885 |
| US-20220332718-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | IRAK1, IRAK4, IRAK2 | TYMS 211/4885CASP7 758/4885CASP1 14/4885 |
| US-10988478-B1 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | IRAK1, IRAK4, IRAK2 | TYMS 297/4885CASP7 1022/4885CASP1 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.