Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HEXA | P06865 | 1/20 | 0.33 |
| ▸ | HEXB | P07686 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 4/20 | 0.32 |
| ▸ | SI | P14410 | 4/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 4/20 | 0.32 |
| ▸ | USP8 | P40818 | 1/20 | 0.32 |
| ▸ | TYMS | P04818 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4345831 | 0.82 | HPGD (0.38) | DCUN1D1NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL17069012 | 0.81 | NUDT1 (0.36) | DCUN1D1NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL24360032 | 0.80 | DCUN1D1 (0.50) | DCUN1D1NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL31429629 | 0.78 | MGAM (0.44) | DCUN1D1NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL17194918 | 0.75 | TLR8 (0.37) | DCUN1D1NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL15527240 | 0.75 | CD44 (0.39) | RENDCUN1D1NPC1ALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL4336639 | 0.73 | TDO2 (0.36) | SMN1; SMN2HTTGAA | |
| SCHEMBL31688431 | 0.73 | AURKA (0.54) | CA9 | |
| SCHEMBL29724732 | 0.72 | KDM4E (0.48) | ALDH1A1HPGDGAAAR | |
| SCHEMBL535697 | 0.72 | KDM4E (0.48) | ALDH1A1HPGDGAAAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9082989-B2 | Platinum (II) di (2-pyrazolyl) benzene chloride analogs and uses | Arizona Board of Regents for and on behalf of Arizona State Univesity (US) | 2015-07-14 | — | — | US | disclosed |
| US-8846940-B2 | Platinum (II) di (2-pyrazolyl) benzene chloride analogs and uses | ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2014-09-30 | — | — | US | disclosed |
| US-20140066628-A1 | Platinum (II) Di (2-Pyrazolyl) Benzene Chloride Analogs and Uses | ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2014-03-06 | — | — | US | disclosed |
| US-20110301351-A1 | Platinum (II) Di (2-Pyrazolyl) Benzene Chloride Analogs and Uses | ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2011-12-08 | — | — | US | disclosed |
| WO-2009086209-A2 | PLATINUM(II) DI(2-PYRAZOLYL)BENZENE CHLORIDE ANALOGS AND USES | ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2009-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301351-A1 | Platinum (II) Di (2-Pyrazolyl) Benzene Chloride Analogs and Uses | PDCD1LG2, PDCD2L, IDH1 | REN 3459/4885MYC 3094/4885DCUN1D1 363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.