SCHEMBL435005

SCHEMBL435005

Clc1cc[c]c(-c2ccc(Cl)cc2Cl)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 1/20 0.45
TP53 P04637 2/20 0.41
HSD11B1 P28845 2/20 0.40
ALDH1A1 P00352 3/20 0.37
RAB9A P51151 3/20 0.37
HSP90AA1 P07900 2/20 0.37
HSP90AB1 P08238 2/20 0.37
KDM4E B2RXH2 1/20 0.37
MGAM O43451 1/20 0.37
GAA P10253 1/20 0.37
SI P14410 1/20 0.37
MGAM2 Q2M2H8 1/20 0.37
TSHR P16473 3/20 0.37
HSD17B10 Q99714 3/20 0.37
CYP3A4 P08684 1/20 0.37
MAPT P10636 1/20 0.36
NPC1 O15118 2/20 0.36
HPGD P15428 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
CRHR1 P34998 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17514748 0.85 NISCH (0.41) AHRTP53HSD11B1RAB9AKDM4E
SCHEMBL435140 0.85 AHR (0.40) AHRTP53HSD11B1ALDH1A1RAB9A
SCHEMBL8527936 0.85 HSD11B1 (0.43) AHRTP53HSD11B1ALDH1A1RAB9A
SCHEMBL4438343 0.83 TP53 (0.41) TP53ALDH1A1RAB9ATSHRHSD17B10
SCHEMBL6682355 0.82 CYP2A6 (0.40) TP53HSD11B1ALDH1A1RAB9AHSP90AA1
SCHEMBL9598658 0.81 AHR (0.37) AHRTP53HSD11B1RAB9AHSP90AA1
SCHEMBL434491 0.80 AHR (0.42) AHRTP53HSD11B1ALDH1A1RAB9A
SCHEMBL433550 0.80 KMO (0.36) AHRHSD11B1S100A4
SCHEMBL15067608 0.79 TP53 (0.35) AHRTP53ALDH1A1TSHRHSD17B10
SCHEMBL6184455 0.78 NPBWR1 (0.47) TP53HSD11B1ALDH1A1RAB9AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0011928-B1 3,5-DIHYDROXYPENTANOIC ESTER DERIVATIVES HAVING ANTIHYPERLIPAEMIC ACTIVITY, THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM SANKYO COMPANY LIMITED (JP) 1982-04-28 EP claimed
EP-2595985-A1 ISOXAZOLE, ISOTHIAZOLE, FURANE AND THIOPHENE COMPOUNDS AS MICROBICIDES Syngenta Participations AG (CH) 2013-05-29 EP disclosed
EP-2595984-A1 MICROBICIDES Syngenta Participations AG (CH) 2013-05-29 EP disclosed
WO-2012010568-A1 MICROBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2012-01-26 WO disclosed
WO-2012010567-A1 ISOXAZOLE, ISOTHIAZOLE, FURANE AND THIOPHENE COMPOUNDS AS MICROBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2012-01-26 WO disclosed
US-5156669-A Fungicides and plant growth regulators BASF AKTIENGESELLSCHAFT (DE) 1992-10-20 US disclosed
US-4530922-A Fungicidal imidazoles and triazoles containing silicon E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-07-23 US disclosed
US-4524168-A AZO DYES CIBA-GEIGY CORPORATION (US) 1985-06-18 US disclosed