SCHEMBL4350074

SCHEMBL4350074

O=C(Cl)C12CCC(CC1)C2

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.42
HTT P42858 3/20 0.42
NPSR1 Q6W5P4 1/20 0.42
KMT2A Q03164 2/20 0.35
HSD11B1 P28845 3/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
THRB P10828 1/20 0.33
GAA P10253 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.32
MAPT P10636 1/20 0.32
LMNA P02545 1/20 0.32
MEN1 O00255 1/20 0.31
CRHBP P24387 1/20 0.31
CRHR2 Q13324 1/20 0.31
MCOLN3 Q8TDD5 1/20 0.31
GLA P06280 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24846052 0.86 ALDH1A1 (0.47) ALDH1A1HTTNPSR1KMT2AHSD11B1
SCHEMBL7723088 0.84 ALDH1A1 (0.33) ALDH1A1HTTNPSR1
SCHEMBL28417551 0.79 ALDH1A1 (0.41) ALDH1A1HTTNPSR1KMT2AHSD11B1
SCHEMBL3079757 0.79 ALDH1A1 (0.41) ALDH1A1HTTNPSR1KMT2AHSD11B1
SCHEMBL21439790 0.78
SCHEMBL15515009 0.77 ALDH1A1 (0.40) ALDH1A1HTTNPSR1KMT2AHSD11B1
SCHEMBL152754 0.77 ALDH1A1 (0.40) ALDH1A1HTTNPSR1KMT2AL3MBTL1
SCHEMBL218350 0.77 ALDH1A1 (0.40) ALDH1A1HTTNPSR1KMT2AHSD11B1
SCHEMBL133056 0.76 HSD11B1 (0.48) ALDH1A1HTTKMT2AHSD11B1L3MBTL1
SCHEMBL9512535 0.75 ALDH1A1 (0.42) ALDH1A1HTTNPSR1KMT2AHSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9862695-B2 Monomer having N-acyl carbamoyl group and lactone skeleton, and polymeric compound DAICEL CORPORATION (JP) 2018-01-09 US disclosed
US-9341947-B2 Resist composition and method of forming resist pattern TOKYO OHKA KOGYO CO., LTD. (JP) 2016-05-17 US disclosed
US-20160060374-A1 MONOMER HAVING N-ACYL CARBAMOYL GROUP AND LACTONE SKELETON, AND POLYMERIC COMPOUND TOKYO OHKA KOGYO CO., LTD. (JP) 2016-03-03 US disclosed
US-20160062236-A1 RESIST COMPOSITION AND METHOD OF FORMING RESIST PATTERN TOKYO OHKA KOGYO CO., LTD. (JP) 2016-03-03 US disclosed
US-8779183-B2 Acid generating agent for chemically amplified resist compositions KOREA KUMHO PETROCHEMICAL CO., LTD. (KR) 2014-07-15 US disclosed
US-20090234155-A1 Acid generating agent for chemically amplified resist compositions KOREA KUMHO PETROCHEMICAL CO., LTD. (KR) 2009-09-17 US disclosed
EP-1910309-A2 CYCLOALKYL AMINO-HYDANTOIN COMPOUNDS AND USE THEREOF FOR ß-SECRETASE MODULATION Wyeth (US) 2008-04-16 EP disclosed
WO-2007016012-A2 CYCLOALKYL AMINO-HYDANTOIN COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION WYETH (US) 2007-02-08 WO disclosed
US-20070027199-A1 Cycloalkyl amino-hydantoin compounds and use thereof for beta-secretase modulation WYETH (US) 2007-02-01 US disclosed
US-4096324-A ANTI-VIRAL, ANTILEUKEMIA THE UPJOHN COMPANY (US) 1978-06-20 US disclosed
US-4088760-A TREATMENT OF ACNE AND OILY SKIN RICHARDSON-MERRELL INC. (US) 1978-05-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160060374-A1 MONOMER HAVING N-ACYL CARBAMOYL GROUP AND LACTONE SKELETON, AND POLYMERIC COMPOUND CNKSR1, NMRAL1, CCNA1 ALDH1A1 2601/4885HTT 1455/4885NPSR1 2044/4885
US-20090234155-A1 Acid generating agent for chemically amplified resist compositions POLM, CBR1, PFAS ALDH1A1 346/4885HTT 3322/4885NPSR1 687/4885
US-20070027199-A1 Cycloalkyl amino-hydantoin compounds and use thereof for beta-secretase modulation BACE1, BACE2, APP ALDH1A1 2594/4885HTT 62/4885NPSR1 1204/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.