Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 3/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.48 |
| ▸ | PRKACG | P22612 | 2/20 | 0.48 |
| ▸ | PRKACB | P22694 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 2/20 | 0.40 |
| ▸ | DDO | Q99489 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638857 | 1.00 | SRC (0.48) | SRCPRKACAPRKACGPRKACBATM | |
| SCHEMBL15730605 | 0.91 | ATM (0.43) | SRCPRKACAPRKACGPRKACBATM | |
| SCHEMBL8299309 | 0.86 | PDE4A (0.40) | SRCPRKACAPRKACGPRKACBATM | |
| SCHEMBL9501265 | 0.85 | SRC (0.45) | SRCPRKACAPRKACGPRKACBATM | |
| SCHEMBL12657284 | 0.85 | ATM (0.54) | ATMPIM1PIM3PIM2HTR2A | |
| SCHEMBL8520252 | 0.84 | SRC (0.39) | SRCPRKACAPRKACGPRKACBATM | |
| SCHEMBL15680180 | 0.83 | SRC (0.42) | SRCPRKACAPRKACGPRKACBATM | |
| SCHEMBL15255990 | 0.82 | LMNA (0.46) | SRCPRKACAPRKACGPRKACBATM | |
| SCHEMBL4417847 | 0.82 | ATM (0.52) | ATMDAOPIM1PIM3PIM2 | |
| SCHEMBL8150276 | 0.80 | SRC (0.52) | SRCPRKACAPRKACGPRKACBHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 564 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10292921-B2 | Hair dyeing process using a composition comprising at least one indol(in)e compound and a polycyclic aromatic compound containing at least ten carbon atoms | L'OREAL (FR) | 2019-05-21 | — | — | US | claimed |
| US-20180092822-A1 | HAIR DYEING PROCESS USING A COMPOSITION COMPRISING AT LEAST ONE INDOL(IN)E COMPOUND AND A POLYCYCLIC AROMATIC COMPOUND CONTAINING AT LEAST TEN CARBON ATOMS | L'OREAL (FR) | 2018-04-05 | — | — | US | claimed |
| EP-2582351-B1 | HAIR DYEING PROCESS USING A COMPOSITION COMPRISING AT LEAST ONE INDOLE OR INDOLINE COMPOUND, A METAL SALT, HYDROGEN PEROXIDE AND A BASIFYING AGENT | L'ORÉAL (FR) | 2017-08-02 | — | — | EP | claimed |
| EP-3148648-A1 | HAIR DYEING PROCESS USING A COMPOSITION COMPRISING AT LEAST ONE INDOL(IN)E COMPOUND AND A POLYCYCLIC AROMATIC COMPOUND CONTAINING AT LEAST TEN CARBON ATOMS | L'OREAL (FR) | 2017-04-05 | — | — | EP | claimed |
| CN-103517703-B | Stain and application thereof | 天野酶制品株式会社 | 2016-11-09 | — | — | CN | claimed |
| EP-2623093-B1 | DYE FOR KERATIN FIBERS USING BILIRUBIN OXIDASE AND INDOLE DERIVATIVES | AMANO ENZYME INC (JP) | 2016-05-25 | — | — | EP | claimed |
| WO-2015181244-A1 | HAIR DYEING PROCESS USING A COMPOSITION COMPRISING AT LEAST ONE INDOL(IN)E COMPOUND AND A POLYCYCLIC AROMATIC COMPOUND CONTAINING AT LEAST TEN CARBON ATOMS | L'OREAL (FR) | 2015-12-03 | — | — | WO | claimed |
| CN-103998016-B | Employ the dyeing of the keratin fiber of indole analog | AMANO ENZYME INC. (JP) | 2015-09-16 | — | — | CN | claimed |
| US-20140359950-A1 | DYEING OF KERATIN FIBERS USING INDOLE ANALOGUE | AMANO ENZYME INC. (JP) | 2014-12-11 | — | — | US | claimed |
| EP-0971682-B2 | DYEING COMPOSITION FOR KERATIN FIBRES AND DYEING METHOD USING SAME | OREAL (FR) | 2009-09-23 | — | — | EP | claimed |
| EP-0425324-A1 | Skin-tanning composition containing indole derivatives and dihydroxyacetone | L'OREAL (FR) | 1991-05-02 | — | — | EP | claimed |
| US-5011500-A | Developing with source of iodide ions and hydrogen peroxide, nitrite source and oxidizing agents; multicompartment kit; oxidation system; color- and washfast | L'OREAL (FR) | 1991-04-30 | — | — | US | claimed |
| EP-0416962-A1 | Keratinous fibers dyeing process with indole dyes and oxidation dye precursors and dyeing agents | L'OREAL (FR) | 1991-03-13 | — | — | EP | claimed |
| EP-0414585-A1 | Keratinous fibres dye composition containing an indole dye and at least a paraphenylenediamine having a secondary amino group and process | L'OREAL (FR) | 1991-02-27 | — | — | EP | claimed |
| EP-0378937-A1 | Process for dyeing keratinous fibres with indole derivatives associated with nitrite, and compositions therefor | L'OREAL (FR) | 1990-07-25 | — | — | EP | claimed |
| EP-0379409-A1 | Products based on polymer particles containing melanine pigments, process for their preparation, and their use, particularly cosmetically | L'OREAL (FR) | 1990-07-25 | — | — | EP | claimed |
| EP-0376776-A2 | Process for dyeing keratinous fibres with hydroxyindole associated with quinone and 1,4-benzoquinone | L'OREAL (FR) | 1990-07-04 | — | — | EP | claimed |
| EP-0348280-A1 | Process for colouring keratinous fibres on the basis of 5,6-dihydroxy-indole or a derivative of indole and at least a salt of a rare-earth metal, and compositions for carrying out the process | L'OREAL (FR) | 1989-12-27 | — | — | EP | claimed |
| US-4885006-A | Process for dyeing keratinous fibres with indole derivatives combined with an iodide | L'OREAL (FR) | 1989-12-05 | — | — | US | claimed |
| EP-0337853-A1 | Procedure of the preversation of the dyeing ability of 5,6-dihydroxy-indole and its derivatives in an aqueous milieu, composition and procedure of dyeing | L'OREAL (FR) | 1989-10-18 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180092822-A1 | HAIR DYEING PROCESS USING A COMPOSITION COMPRISING AT LEAST ONE INDOL(IN)E COMPOUND AND A POLYCYCLIC AROMATIC COMPOUND CONTAINING AT LEAST TEN CARBON ATOMS | KRT18, TYR, INCENP | SRC 2152/4885PRKACA 111/4885PRKACG 168/4885 |
| US-10292921-B2 | Hair dyeing process using a composition comprising at least one indol(in)e compound and a polycyclic aromatic compound containing at least ten carbon atoms | KRT18, TYR, INCENP | SRC 2066/4885PRKACA 92/4885PRKACG 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.