Sugi Predict

Sugi Predict / Compounds / SCHEMBL435065

SCHEMBL435065

SCHEMBL435065

CO/N=C(\COc1ccc(COc2ccc(C(=O)CC(=O)OC)cc2)cc1)c1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FFAR1 O14842 2/20 0.64
▸ SMN1; SMN2 Q16637 6/20 0.52
▸ RAB9A P51151 5/20 0.52
▸ MAPT P10636 4/20 0.52
▸ ALDH1A1 P00352 3/20 0.52
▸ HTT P42858 2/20 0.52
▸ GAA P10253 1/20 0.52
▸ NPC1 O15118 4/20 0.49
▸ L3MBTL1 Q9Y468 2/20 0.48
▸ MAPK1 P28482 1/20 0.47
▸ MEN1 O00255 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ PLA2G4B P0C869 2/20 0.46
▸ MAOB P27338 1/20 0.46
▸ EGFR P00533 2/20 0.46
▸ POLB P06746 1/20 0.45
▸ NR4A1 P22736 1/20 0.45
▸ NR4A2 P43354 1/20 0.45
▸ NR4A3 Q92570 1/20 0.45
▸ PPARG P37231 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL435066 1.00 FFAR1 (0.64) FFAR1SMN1; SMN2RAB9AMAPTALDH1A1
SCHEMBL10262172 0.93 FFAR1 (0.67) FFAR1SMN1; SMN2RAB9AMAPTALDH1A1
SCHEMBL15239251 0.87 FFAR1 (0.71) FFAR1SMN1; SMN2RAB9AMAPTALDH1A1
SCHEMBL10258712 0.87 FFAR1 (0.71) FFAR1SMN1; SMN2RAB9AMAPTALDH1A1
SCHEMBL434771 0.87 FFAR1 (0.64) FFAR1SMN1; SMN2RAB9AMAPTALDH1A1
SCHEMBL15239468 0.87 FFAR1 (0.64) FFAR1SMN1; SMN2RAB9AMAPTALDH1A1
SCHEMBL434770 0.87 FFAR1 (0.64) FFAR1SMN1; SMN2RAB9AMAPTALDH1A1
SCHEMBL10267704 0.86 FFAR1 (0.76) FFAR1SMN1; SMN2RAB9AMAPTALDH1A1
SCHEMBL15239401 0.86 FFAR1 (0.76) FFAR1SMN1; SMN2RAB9AMAPTALDH1A1
SCHEMBL22653334 0.83 FFAR1 (0.69) FFAR1SMN1; SMN2RAB9AMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2595952-B1 AGONISTS OF GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2020-11-18 — — EP disclosed
EP-2595952-B1 AGONISTS OF GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2020-11-18 — — EP disclosed
US-9278915-B2 Agonists of GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2016-03-08 — — US disclosed
US-9278915-B2 Agonists of GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2016-03-08 — — US disclosed
US-9278915-B2 Agonists of GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2016-03-08 — — US disclosed
US-20130237571-A1 AGONISTS OF GPR40 Conexios Life Sciences PVT. LTD. (IN) 2013-09-12 — — US disclosed
US-20130237571-A1 AGONISTS OF GPR40 Conexios Life Sciences PVT. LTD. (IN) 2013-09-12 — — US disclosed
US-20130237571-A1 AGONISTS OF GPR40 Conexios Life Sciences PVT. LTD. (IN) 2013-09-12 — — US disclosed
EP-2595952-A1 AGONISTS OF GPR40 Connexios Life Sciences Pvt. Ltd. (IN) 2013-05-29 — — EP disclosed
WO-2012011125-A1 AGONISTS OF GPR40 CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) 2012-01-26 — — WO disclosed
WO-2012011125-A1 AGONISTS OF GPR40 CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) 2012-01-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130237571-A1 AGONISTS OF GPR40 GPR65, GPR55, GPR68 FFAR1 24/4885SMN1; SMN2 2796/4885RAB9A 2043/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.