Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.60 |
| ▸ | SIRT2 | Q8IXJ6 | 10/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | GNG2 | P59768 | 1/20 | 0.37 |
| ▸ | GNB1 | P62873 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2199584 | 0.87 | BRD4 (0.56) | BRD4SIRT2MAPTKDM4EALOX15 | |
| SCHEMBL2199582 | 0.81 | BRD4 (0.40) | BRD4MAPTGAAGFERRAB9A | |
| SCHEMBL4351557 | 0.81 | BRD4 (0.46) | BRD4SIRT2MAPTKDM4ETP53 | |
| SCHEMBL2199580 | 0.78 | BRD4 (0.41) | BRD4 | |
| SCHEMBL2195873 | 0.77 | BRD4 (0.47) | BRD4MAPTKDM4EHPGDHSD17B10 | |
| SCHEMBL2201619 | 0.76 | BRD4 (0.45) | BRD4 | |
| SCHEMBL2196975 | 0.76 | IKBKB (0.47) | BRD4KDM4E | |
| SCHEMBL2196845 | 0.76 | CDC7 (0.51) | BRD4RAB9A | |
| SCHEMBL2198463 | 0.76 | BRD4 (0.52) | BRD4 | |
| SCHEMBL16044649 | 0.75 | BRD4 (1.00) | BRD4SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116530-A1 | NOVEL PYRROLE DERIVATIVE HAVING UREIDE GROUP AND AMINOCARBONYL GROUP AS SUBSTITUENTS | Santen Pharmaceutical Co., Ltd (JP) | 2009-11-11 | — | — | EP | disclosed |