Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4347058 | 0.92 | ALDH1A1 (0.42) | MAPTMAP4K4LMNAL3MBTL1NAMPT | |
| SCHEMBL4344098 | 0.89 | NAMPT (0.39) | MAPTMAP4K4LMNANAMPTALDH1A1 | |
| SCHEMBL4337480 | 0.84 | MAP4K4 (0.48) | MAPTMAP4K4LMNAL3MBTL1NAMPT | |
| SCHEMBL4351602 | 0.79 | GAA (0.44) | MAPTLMNAL3MBTL1GAAALDH1A1 | |
| SCHEMBL4341123 | 0.79 | LMNA (0.37) | MAPTMAP4K4LMNAGAAALDH1A1 | |
| SCHEMBL9241874 | 0.78 | LMNA (0.50) | LMNAL3MBTL1GAAALDH1A1KDM4E | |
| SCHEMBL4341686 | 0.77 | ALOX15 (0.43) | MAPTALOX15SRC | |
| SCHEMBL4347805 | 0.77 | KDM4C (0.48) | MAP4K4NAMPTHTTKDM4C | |
| SCHEMBL9239326 | 0.76 | LMNA (0.48) | LMNAL3MBTL1GAAALDH1A1HTT | |
| SCHEMBL4345204 | 0.76 | MAP4K4 (0.46) | MAPTMAP4K4LMNAL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501797-B1 | 3-(SUBSTITUTED AMINO)-1H-INDOLE-2-CARBOXYLIC ACID ESTER AND 3-(SUBSTITUTED AMINO)-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ESTER DERIVATIVES AS INTERLEUKIN-4 GENE EXPRESSION INHIBITORS | AVENTIS PHARMA INC (US) | 2009-08-05 | — | — | EP | claimed |