Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | VSIG8 | P0DPA2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4341686 | 0.92 | ALOX15 (0.43) | MAPTGCGRSRC | |
| SCHEMBL4343913 | 0.88 | KMT2A (0.43) | GAAALDH1A1HPGDMAPTALOX5 | |
| SCHEMBL4347024 | 0.85 | KDM4E (0.47) | GAAALDH1A1HPGDCYP1A2MAPT | |
| SCHEMBL4334687 | 0.83 | CYP1A2 (0.43) | GAAALDH1A1HPGDCYP1A2MAPT | |
| SCHEMBL4342254 | 0.83 | GAA (0.60) | GAAALDH1A1HPGDCYP1A2XBP1 | |
| SCHEMBL4339512 | 0.81 | MAPK14 (0.36) | ALDH1A1MAPTALOX5KDM4EHSD17B10 | |
| SCHEMBL4351607 | 0.79 | MAPT (0.41) | GAAALDH1A1HPGDCYP1A2CYP2C19 | |
| SCHEMBL4346788 | 0.79 | MMP2 (0.41) | GAAALDH1A1HPGDMAPTALOX5 | |
| SCHEMBL4333018 | 0.79 | KIF11 (0.43) | GAAALDH1A1MAPTNPSR1L3MBTL1 | |
| SCHEMBL9240047 | 0.78 | ALDH1A1 (0.50) | ALDH1A1HPGDCYP1A2XBP1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501797-B1 | 3-(SUBSTITUTED AMINO)-1H-INDOLE-2-CARBOXYLIC ACID ESTER AND 3-(SUBSTITUTED AMINO)-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ESTER DERIVATIVES AS INTERLEUKIN-4 GENE EXPRESSION INHIBITORS | AVENTIS PHARMA INC (US) | 2009-08-05 | — | — | EP | claimed |