Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.62 |
| ▸ | STK4 | Q13043 | 4/20 | 0.62 |
| ▸ | STK3 | Q13188 | 4/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | PRKACA | P17612 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 3/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4350720 | 0.83 | STK4 (0.68) | LRRK2STK4STK3MAP4K4 | |
| SCHEMBL12438584 | 0.83 | LRRK2 (0.55) | LRRK2STK4STK3MAP4K4CDC7 | |
| SCHEMBL8107168 | 0.83 | LRRK2 (0.62) | LRRK2STK4STK3MAP4K4CDK2 | |
| SCHEMBL8114068 | 0.83 | ADK (0.49) | LRRK2STK4STK3 | |
| SCHEMBL8112985 | 0.82 | CCNT1 (0.48) | LRRK2STK4STK3MAP4K4CDK2 | |
| SCHEMBL4352960 | 0.82 | LRRK2 (0.58) | LRRK2STK4STK3MAP4K4CDC7 | |
| SCHEMBL7021288 | 0.82 | LRRK2 (0.63) | LRRK2STK4STK3MAP4K4CDK2 | |
| SCHEMBL31531349 | 0.80 | FLT3 (0.51) | LRRK2STK4STK3MAP4K4RIPK2 | |
| SCHEMBL7013879 | 0.80 | LRRK2 (0.65) | LRRK2STK4STK3MAP4K4 | |
| SCHEMBL15401813 | 0.79 | LRRK2 (0.83) | LRRK2STK4STK3CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |
| EP-0888353-B1 | N-7-HETEROCYCLYL PYRROLO [2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2003-07-09 | — | — | EP | disclosed |
| US-6051577-A | TYROSINE INHIBITORS; BONE DISORDERS | NOVARTIS AG (CH) | 2000-04-18 | — | — | US | disclosed |