Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 7/20 | 0.34 |
| ▸ | CA2 | P00918 | 7/20 | 0.34 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | BRD1 | O95696 | 1/20 | 0.32 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4355952 | 0.78 | BRPF1 (0.47) | TRIM24MEN1KMT2ASMN1; SMN2BRD4 | |
| SCHEMBL1811055 | 0.77 | GSPT1 (0.45) | MEN1KMT2APKMLMNABRD4 | |
| SCHEMBL1812408 | 0.77 | MEN1 (0.46) | MEN1KMT2APTGDR2PKMSMN1; SMN2 | |
| SCHEMBL3909458 | 0.76 | PKM (0.51) | MEN1KMT2APKMSMN1; SMN2TP53 | |
| SCHEMBL3903960 | 0.76 | LMNA (0.42) | MEN1KMT2APKMLMNABRD4 | |
| SCHEMBL3906955 | 0.76 | PTPN2 (0.43) | PKMSMN1; SMN2TP53LMNAHTT | |
| SCHEMBL3908711 | 0.75 | BRPF1 (0.55) | TRIM24MEN1KMT2ABRD4BRD1 | |
| SCHEMBL3909496 | 0.74 | HSD17B2 (0.49) | KMT2ATP53MAPT | |
| SCHEMBL3916133 | 0.73 | BRD4 (0.42) | TRIM24PKMSMN1; SMN2TP53BRD4 | |
| SCHEMBL3906469 | 0.73 | BRPF1 (0.54) | TRIM24BRD4BRD1BRPF1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-B1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | EP | claimed |