Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 3/20 | 0.47 |
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | BRD1 | O95696 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1812553 | 0.83 | BRPF1 (0.46) | BRPF1BRD4CYP2D6PARP1PGR | |
| SCHEMBL4352199 | 0.83 | BRPF1 (0.44) | BRPF1BRD4CYP2D6PARP1GRIN1 | |
| SCHEMBL1812628 | 0.83 | BRPF1 (0.41) | BRPF1BRD4CYP2D6PARP1SMN1; SMN2 | |
| SCHEMBL3908711 | 0.79 | BRPF1 (0.55) | BRPF1BRD4TRIM24MEN1MAPT | |
| SCHEMBL3909458 | 0.78 | PKM (0.51) | BRPF1MEN1MAPTHTTKMT2A | |
| SCHEMBL3903960 | 0.78 | LMNA (0.42) | BRPF1BRD4CYP2D6MEN1MAPT | |
| SCHEMBL4353068 | 0.78 | CA1 (0.34) | BRPF1BRD4CYP2D6TRIM24MEN1 | |
| SCHEMBL1812408 | 0.78 | MEN1 (0.46) | BRPF1ALDH1A1MEN1POLBMAPT | |
| SCHEMBL1811055 | 0.78 | GSPT1 (0.45) | BRD4CYP2D6ALDH1A1MEN1MAPT | |
| SCHEMBL3906469 | 0.77 | BRPF1 (0.54) | BRPF1BRD4PGRTRIM24MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-B1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | EP | claimed |