SCHEMBL435344

SCHEMBL435344

CON=C(COc1ccc(COc2ccc(C=O)c(OC)c2)cc1)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 2/20 0.57
ERN1 O75460 2/20 0.45
PTPN1 P18031 1/20 0.44
ALDH1A1 P00352 2/20 0.43
ROCK2 O75116 1/20 0.43
ROCK1 Q13464 1/20 0.43
TUBB1 Q9H4B7 1/20 0.42
MAPT P10636 3/20 0.42
KDM4E B2RXH2 1/20 0.42
POLB P06746 1/20 0.42
HTT P42858 1/20 0.42
RECQL P46063 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
TDP1 Q9NUW8 2/20 0.42
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
MAOB P27338 2/20 0.41
PLA2G4B P0C869 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.40
APP P05067 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL435343 1.00 FFAR1 (0.57) FFAR1ERN1PTPN1ALDH1A1ROCK2
SCHEMBL22668030 0.91 FFAR1 (0.55) FFAR1ERN1PTPN1ALDH1A1MAPT
SCHEMBL15239317 0.88 FFAR1 (0.56) FFAR1PTPN1ALDH1A1MAPTKDM4E
SCHEMBL10258506 0.88 FFAR1 (0.56) FFAR1PTPN1ALDH1A1MAPTKDM4E
SCHEMBL15239318 0.88 FFAR1 (0.56) FFAR1PTPN1ALDH1A1MAPTKDM4E
SCHEMBL15239336 0.88 FFAR1 (0.56) FFAR1PTPN1ALDH1A1MAPTKDM4E
SCHEMBL22668359 0.86 FFAR1 (0.52) FFAR1PTPN1ALDH1A1MAPTKDM4E
SCHEMBL10260721 0.84 FFAR1 (0.52) FFAR1PTPN1ALDH1A1MAPTKDM4E
SCHEMBL15238969 0.84 FFAR1 (0.65) FFAR1ALDH1A1MAPTPOLBHTT
SCHEMBL10267410 0.84 FFAR1 (0.65) FFAR1ALDH1A1MAPTPOLBHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2595952-B1 AGONISTS OF GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2020-11-18 EP disclosed
US-9278915-B2 Agonists of GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2016-03-08 US disclosed
US-20130237571-A1 AGONISTS OF GPR40 Conexios Life Sciences PVT. LTD. (IN) 2013-09-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130237571-A1 AGONISTS OF GPR40 GPR65, GPR55, GPR68 FFAR1 24/4885ERN1 3847/4885PTPN1 2995/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.