Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VKORC1 | Q9BQB6 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NQO1 | P15559 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27152753 | 0.85 | ESR1 (0.46) | VKORC1CYP1A2CYP2C19NQO1ALDH1A1 | |
| SCHEMBL5478821 | 0.79 | VKORC1 (0.51) | VKORC1CYP1A2CYP2C19NQO1ALDH1A1 | |
| SCHEMBL7192591 | 0.79 | GAA (0.57) | VKORC1CYP1A2CYP2C19NQO1ALDH1A1 | |
| SCHEMBL3988877 | 0.79 | GAA (0.57) | VKORC1CYP1A2CYP2C19NQO1ALDH1A1 | |
| SCHEMBL7143392 | 0.76 | VKORC1 (0.71) | VKORC1CYP1A2CYP2C19NQO1ALDH1A1 | |
| SCHEMBL3981987 | 0.72 | VKORC1 (0.45) | VKORC1CYP1A2CYP2C19NQO1ALDH1A1 | |
| SCHEMBL7140693 | 0.72 | CA12 (0.52) | VKORC1CYP1A2CYP2C19NQO1ALDH1A1 | |
| SCHEMBL4530526 | 0.71 | SRC (0.52) | VKORC1CYP1A2CYP2C19NQO1ALDH1A1 | |
| SCHEMBL28455189 | 0.70 | ALDH1A1 (0.47) | VKORC1CYP1A2CYP2C19NQO1ALDH1A1 | |
| SCHEMBL5677951 | 0.70 | MAOA (0.47) | VKORC1CYP1A2CYP2C19NQO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090005436-A1 | Substituted Aminoalkyl- and Amidoalkyl-Benzopyran Derivatives | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2009-01-01 | — | — | US | disclosed |
| CN-101137638-A | Substituted aminoalkyl-and amidoalkyl-benzopyran derivatives | NEWRON PHARM SPA (IT) | 2008-03-05 | — | — | CN | disclosed |
| EP-1863784-A1 | SUBSTITUTED AMINOALKYL- AND AMIDOALKYL-BENZOPYRAN DERIVATIVES | Newron Pharmaceuticals S.p.A. (IT) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006102958-A1 | SUBSTITUTED AMINOALKYL- AND AMIDOALKYL-BENZOPYRAN DERIVATIVES | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005436-A1 | Substituted Aminoalkyl- and Amidoalkyl-Benzopyran Derivatives | MAOB, MAOA, AOC3 | VKORC1 1290/4885CYP1A2 56/4885CYP2C19 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.