Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 3/20 | 0.51 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1808705 | 0.91 | PKM (0.51) | HPGDPKMTAS2R14TSHRSMN1; SMN2 | |
| SCHEMBL1811184 | 0.83 | NR1I2 (0.58) | PKMSMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL1819641 | 0.81 | PGR (0.57) | PKMMAPTLMNABRD4 | |
| SCHEMBL1843607 | 0.81 | PKM (0.50) | PKMSMN1; SMN2MAPTLMNAMEN1 | |
| SCHEMBL3915102 | 0.81 | PTGDR2 (0.48) | PKMTSHRMAPTALDH1A1LMNA | |
| SCHEMBL1813239 | 0.80 | NR1I2 (0.60) | MAPTMEN1KMT2A | |
| SCHEMBL1810608 | 0.80 | BRD4 (0.55) | HPGDPKMSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL1818340 | 0.79 | PGR (0.48) | — | |
| SCHEMBL1807440 | 0.79 | NR3C1 (0.51) | TSHRMAPTMEN1KMT2AGAA | |
| SCHEMBL3911526 | 0.79 | MAPT (0.53) | TSHRMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-B1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | EP | claimed |