Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.67 |
| ▸ | NAMPT | P43490 | 2/20 | 0.60 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | RORC | P51449 | 3/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4347012 | 0.88 | MTOR (0.56) | MTORNAMPTPRMT3CNR1RORC | |
| SCHEMBL4348431 | 0.87 | MTOR (0.68) | MTORNAMPTPRMT3CNR1RORC | |
| SCHEMBL4348348 | 0.85 | MTOR (0.69) | MTORNAMPTPRMT3CNR1RORC | |
| SCHEMBL6229028 | 0.85 | MTOR (0.56) | MTORNAMPTPRMT3CNR1RORC | |
| SCHEMBL4357497 | 0.84 | MEN1 (0.61) | MAPT | |
| SCHEMBL4350068 | 0.84 | MTOR (0.67) | MTORNAMPTPRMT3CNR1TRPV1 | |
| SCHEMBL4350084 | 0.84 | MTOR (0.56) | MTORNAMPTPRMT3CNR1TRPV1 | |
| SCHEMBL4348880 | 0.83 | EPHX2 (0.69) | MTORTRPV1CA1CA2CA9 | |
| SCHEMBL4350061 | 0.82 | MTOR (0.55) | MTORCA1CA2CA9RAB9A | |
| SCHEMBL4357504 | 0.80 | TRPV1 (0.61) | MTORNAMPTTRPV1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | claimed |
| CN-1701061-A | Novel compounds for inhibiting rotamase enzymes and uses thereof | JERINI AG (DE) | 2005-11-23 | — | — | CN | claimed |
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | disclosed |