Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.43 |
| ▸ | CTSL | P07711 | 4/20 | 0.43 |
| ▸ | CTSB | P07858 | 4/20 | 0.43 |
| ▸ | CTSH | P09668 | 3/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17939425 | 0.76 | CTSK (0.41) | CTSKCTSLCTSBCTSHSLC1A3 | |
| SCHEMBL18420036 | 0.76 | CTSK (0.38) | CTSKCTSLCTSBCTSHALOX5 | |
| SCHEMBL18420035 | 0.76 | CTSK (0.38) | CTSKCTSLCTSBCTSHALOX5 | |
| SCHEMBL16563050 | 0.76 | CTSK (0.41) | CTSKCTSLCTSBCTSHSLC1A3 | |
| SCHEMBL7953083 | 0.76 | CTSK (0.41) | CTSKCTSLCTSBCTSHSLC1A3 | |
| SCHEMBL7300079 | 0.75 | REN (0.41) | CTSKCTSLCTSBCTSHMETAP2 | |
| SCHEMBL10069254 | 0.75 | ALOX5 (0.42) | CTSKSLC1A3SLC1A2SLC1A1ALOX5 | |
| SCHEMBL12240918 | 0.75 | ALOX5 (0.42) | CTSKSLC1A3SLC1A2SLC1A1ALOX5 | |
| SCHEMBL15686538 | 0.75 | ALOX5 (0.42) | CTSKSLC1A3SLC1A2SLC1A1ALOX5 | |
| SCHEMBL7495648 | 0.74 | CTSK (0.39) | CTSKCTSLCTSBCTSHSLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595960-A1 | SALT AND SOLVATES OF A TETRAHYDROISOQUINOLINE DERIVATIVE | Spinifex Pharmaceuticals Pty Ltd (AU) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012010843-A1 | SALT AND SOLVATES OF A TETRAHYDROISOQUINOLINE DERIVATIVE | SPINIFEX PHARMACEUTICALS PTY LTD (AU) | 2012-01-26 | — | — | WO | disclosed |