Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.41 |
| ▸ | METAP2 | P50579 | 8/20 | 0.40 |
| ▸ | METAP1 | P53582 | 4/20 | 0.40 |
| ▸ | CTSK | P43235 | 4/20 | 0.38 |
| ▸ | CTSL | P07711 | 3/20 | 0.36 |
| ▸ | CTSB | P07858 | 3/20 | 0.36 |
| ▸ | CTSH | P09668 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294628 | 0.82 | REN (0.39) | RENMETAP2METAP1CTSKCTSL | |
| SCHEMBL7281935 | 0.80 | CTSK (0.40) | RENMETAP2METAP1CTSKCTSL | |
| Acetic Acid SCHEMBL7300070 | 0.78 | REN (0.49) | RENMETAP2METAP1 | |
| SCHEMBL435530 | 0.75 | CTSK (0.43) | METAP2METAP1CTSKCTSLCTSB | |
| SCHEMBL5709584 | 0.74 | REN (0.41) | RENMETAP2METAP1CTSKCTSL | |
| SCHEMBL7301592 | 0.73 | REN (0.49) | RENMETAP2METAP1 | |
| SCHEMBL7272185 | 0.73 | REN (0.49) | RENMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL9848324 | 0.72 | REN (0.47) | RENMETAP2METAP1 | |
| SCHEMBL10408952 | 0.72 | METAP2 (0.55) | RENMETAP2METAP1 | |
| SCHEMBL7338344 | 0.71 | REN (0.44) | RENMETAP2METAP1CTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0341602-A2 | Renin-inhibiting functionalized peptidyl aminodiols and - triols | ABBOTT LABORATORIES (US) | 1989-11-15 | — | — | EP | disclosed |