Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.67 |
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.67 |
| ▸ | NAMPT | P43490 | 2/20 | 0.53 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.45 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348892 | 0.84 | MAPT (0.54) | MTORTRPV1MEN1KMT2A | |
| SCHEMBL4347125 | 0.82 | TRPV1 (0.65) | MTORTRPV1CXCR1 | |
| SCHEMBL4350115 | 0.81 | BAZ1A (0.65) | MTORTRPV1MEN1KMT2ACXCR1 | |
| SCHEMBL4357690 | 0.80 | CHRNA7 (0.64) | MTORTRPV1NAMPTPRMT3MEN1 | |
| SCHEMBL26625460 | 0.79 | MTOR (0.71) | MTORTRPV1NAMPTPRMT3MEN1 | |
| SCHEMBL24575984 | 0.78 | MTOR (0.69) | MTORTRPV1NAMPTPRMT3MEN1 | |
| SCHEMBL4347640 | 0.77 | MTOR (0.57) | MTORTRPV1NAMPTPRMT3ATG4B | |
| SCHEMBL4357504 | 0.77 | TRPV1 (0.61) | MTORTRPV1NAMPTMEN1KMT2A | |
| SCHEMBL4350084 | 0.76 | MTOR (0.56) | MTORTRPV1NAMPTPRMT3MEN1 | |
| SCHEMBL4343320 | 0.75 | TRPV1 (0.63) | MTORTRPV1NAMPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065760-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES AND USE THEREOF | JERINI AG (DE) | 2011-03-17 | — | — | US | claimed |
| CN-100546977-C | Suppress the new compound and the application thereof of rotamase | JERINI AG (DE) | 2009-10-07 | — | — | CN | claimed |
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | claimed |
| US-20070054904-A1 | Phenol derivatives and their use as rotamase inhibitors | JERINI AG (DE) | 2007-03-08 | — | — | US | claimed |
| CN-1701061-A | Novel compounds for inhibiting rotamase enzymes and uses thereof | JERINI AG (DE) | 2005-11-23 | — | — | CN | claimed |
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065760-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES AND USE THEREOF | NR1I3, NR1D1, NR1D2 | MTOR 1379/4885TRPV1 2328/4885NAMPT 4392/4885 |
| US-20070054904-A1 | Phenol derivatives and their use as rotamase inhibitors | NR1I3, NR1D1, NR1D2 | MTOR 1296/4885TRPV1 2320/4885NAMPT 3066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.