Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN1 | O60741 | 7/20 | 0.54 |
| ▸ | HCN4 | Q9Y3Q4 | 6/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4353725 | 0.92 | HCN4 (0.54) | HCN1HCN4TP53SLC6A9ALDH1A1 | |
| SCHEMBL4350496 | 0.91 | HCN4 (0.55) | HCN1HCN4TP53SLC6A9ALDH1A1 | |
| SCHEMBL4355954 | 0.90 | HCN1 (0.62) | HCN1HCN4TP53OPRM1SIGMAR1 | |
| SCHEMBL3688404 | 0.90 | HCN4 (0.63) | HCN1HCN4TP53OPRM1SIGMAR1 | |
| SCHEMBL4357339 | 0.90 | HCN4 (0.63) | HCN1HCN4TP53OPRM1SIGMAR1 | |
| SCHEMBL4359934 | 0.89 | HCN1 (0.42) | HCN1HCN4TP53OPRM1SIGMAR1 | |
| SCHEMBL13706728 | 0.89 | HCN1 (0.42) | HCN1HCN4TP53OPRM1SIGMAR1 | |
| SCHEMBL4351759 | 0.87 | HCN4 (0.60) | HCN1HCN4TP53OPRM1SIGMAR1 | |
| SCHEMBL4358058 | 0.85 | HCN1 (0.42) | HCN1HCN4LMNASLC6A9ALDH1A1 | |
| SCHEMBL13706822 | 0.85 | HCN1 (0.42) | HCN1HCN4LMNASLC6A9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108551-A2 | HETEROARYL AMIDE ANALOGUES | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | claimed |
| WO-2009108551-A2 | HETEROARYL AMIDE ANALOGUES | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | disclosed |