Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.70 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.70 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.70 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.70 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6768746 | 0.84 | CHRNB2 (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4SIGMAR1 | |
| SCHEMBL6768744 | 0.84 | CHRNB2 (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4SIGMAR1 | |
| SCHEMBL13539860 | 0.83 | CHRNB2 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4SIGMAR1 | |
| SCHEMBL10575836 | 0.83 | SIGMAR1 (0.64) | CHRNB2CHRNB4CHRNA3CHRNA4SIGMAR1 | |
| SCHEMBL13504094 | 0.79 | CHRNB2 (0.70) | CHRNB2CHRNB4CHRNA3CHRNA4SIGMAR1 | |
| SCHEMBL24495194 | 0.78 | CHRNB2 (0.68) | CHRNB2CHRNB4CHRNA3CHRNA4SIGMAR1 | |
| SCHEMBL13503963 | 0.77 | SIGMAR1 (0.73) | CHRNB2CHRNB4CHRNA3CHRNA4SIGMAR1 | |
| SCHEMBL24495154 | 0.76 | CHRNB2 (0.64) | CHRNB2CHRNB4CHRNA3CHRNA4SIGMAR1 | |
| SCHEMBL13503742 | 0.76 | CHRNB2 (0.64) | CHRNB2CHRNB4CHRNA3CHRNA4SIGMAR1 | |
| SCHEMBL11492527 | 0.75 | SIGMAR1 (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976525-A4 | PIPERIDINE AND PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2009-07-15 | — | — | EP | disclosed |
| EP-1976525-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES | M's Science Corporation (JP) | 2008-10-08 | — | — | EP | disclosed |
| EP-1931347-A2 | PIPERAZINE DERIVATIVES | M's Science Corporation (JP) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007089462-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES | M'S SCIENCE CORPORATION (JP) | 2007-08-09 | — | — | WO | disclosed |
| WO-2007021545-A2 | PIPERAZINE DERIVATIVES | M'S SCIENCE CORPORATION (JP) | 2007-02-22 | — | — | WO | disclosed |
| EP-1130018-A1 | DRUG DEPENDENCE REMEDIES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-09-05 | — | — | EP | disclosed |
| JP-2000204041-A | THERAPEUTIC AGENT FOR DRUG DEPENDENCE | SANTEN PHARMACEUT CO LTD | 2000-07-25 | — | — | JP | disclosed |