Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.58 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.58 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HBB | P68871 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6768746 | 1.00 | CHRNB2 (0.58) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM3 | |
| SCHEMBL4356995 | 0.84 | CHRNB2 (0.70) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM3 | |
| SCHEMBL8571620 | 0.73 | OPRD1 (0.42) | CHRNA4CXCR4ALDH1A1LMNACHRM1 | |
| SCHEMBL7268687 | 0.72 | OPRD1 (0.53) | CHRNB2CHRNB4CHRNA3CHRNA4OPRK1 | |
| SCHEMBL7258711 | 0.72 | OPRD1 (0.53) | CHRNB2CHRNB4CHRNA3CHRNA4OPRK1 | |
| SCHEMBL10365378 | 0.72 | CHRNB2 (0.68) | CHRNB2CHRNB4CHRNA3CHRNA4SLC6A4 | |
| SCHEMBL10365377 | 0.72 | CHRNB2 (0.68) | CHRNB2CHRNB4CHRNA3CHRNA4SLC6A4 | |
| SCHEMBL10365376 | 0.72 | CHRNB2 (0.68) | CHRNB2CHRNB4CHRNA3CHRNA4SLC6A4 | |
| SCHEMBL10575836 | 0.70 | SIGMAR1 (0.64) | CHRNB2CHRNB4CHRNA3CHRNA4CHRM3 | |
| SCHEMBL13539860 | 0.70 | CHRNB2 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686353-B1 | PREVENTING BLOOD MONOCYTES AND LYMPHOCYTES FROM INFILTRATING TISSUE | TEIJIN INTELLECTUAL PROPERTY CENTER LIMITED (JP) | 2004-02-03 | — | — | US | disclosed |
| EP-0914319-B1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LTD (JP) | 2001-11-21 | — | — | EP | disclosed |
| EP-0914319-A1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LIMITED (JP) | 1999-05-12 | — | — | EP | disclosed |
| WO-1997044329-A9 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | — | 1998-03-12 | — | — | WO | disclosed |
| WO-1997044329-A1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LIMITED (JP) | 1997-11-27 | — | — | WO | disclosed |