Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.64 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.64 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.64 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.64 |
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.51 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13503963 | 0.83 | SIGMAR1 (0.73) | CHRNB2CHRNB4CHRNA3CHRNA4SIGMAR1 | |
| SCHEMBL13503780 | 0.79 | CHRNB2 (0.60) | CHRNB2CHRNB4CHRNA3CHRNA4SIGMAR1 | |
| SCHEMBL28351310 | 0.77 | SLC18A3 (0.57) | SLC18A3SIGMAR1DRD2CARM1PRMT6 | |
| SCHEMBL175904 | 0.77 | SLC18A3 (0.57) | SLC18A3SIGMAR1DRD2CARM1PRMT6 | |
| SCHEMBL13504094 | 0.76 | CHRNB2 (0.70) | CHRNB2CHRNB4CHRNA3CHRNA4SIGMAR1 | |
| SCHEMBL4356995 | 0.76 | CHRNB2 (0.70) | CHRNB2CHRNB4CHRNA3CHRNA4SIGMAR1 | |
| SCHEMBL8967407 | 0.74 | SLC18A3 (0.73) | SLC18A3SIGMAR1DRD2CARM1PRMT6 | |
| SCHEMBL22485473 | 0.74 | DRD2 (0.58) | SLC18A3SIGMAR1DRD2CARM1PRMT6 | |
| SCHEMBL22468789 | 0.74 | DRD2 (0.58) | SLC18A3SIGMAR1DRD2CARM1PRMT6 | |
| SCHEMBL22468791 | 0.74 | DRD2 (0.58) | SLC18A3SIGMAR1DRD2CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12043602-B2 | Fendiline derivatives | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-07-23 | — | — | US | disclosed |
| US-12043602-B2 | Fendiline derivatives | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-07-23 | — | — | US | disclosed |
| US-20220177440-A1 | Fendiline Derivatives | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2022-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12043602-B2 | Fendiline derivatives | CYP11B2, CYP3A7, CYP4F2 | CHRNB2 300/4885CHRNB4 430/4885CHRNA3 451/4885 |
| US-20220177440-A1 | Fendiline Derivatives | CYP11B2, CYP3A7, CYP4F2 | CHRNB2 300/4885CHRNB4 430/4885CHRNA3 451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.