SCHEMBL4358642

SCHEMBL4358642

C#Cc1ccc(C(=O)Oc2ccccc2C(C)(C)c2ccccc2OC(=O)c2ccc(C#C)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.41
KMT2A Q03164 4/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
ATM Q13315 1/20 0.41
NPSR1 Q6W5P4 2/20 0.41
SLC6A3 Q01959 1/20 0.41
PRSS1 P07477 2/20 0.40
ACR P10323 2/20 0.40
RXRA P19793 1/20 0.39
RXRB P28702 1/20 0.39
RXRG P48443 1/20 0.39
L3MBTL1 Q9Y468 2/20 0.38
ESR1 P03372 2/20 0.38
ESR2 Q92731 2/20 0.38
SERPINE1 P05121 1/20 0.37
MEN1 O00255 1/20 0.37
JAK2 O60674 1/20 0.37
USP2 O75604 1/20 0.37
GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14118889 0.84 KMT2A (0.58) MAPTKMT2ASMN1; SMN2TDP1ATM
SCHEMBL9153761 0.82 NR1H4 (0.49) MAPTKMT2ASMN1; SMN2TDP1ATM
SCHEMBL9156958 0.77 NR1H4 (0.53) MAPTKMT2ATDP1NPSR1MEN1
SCHEMBL1192182 0.77 MAPT (0.53) MAPTKMT2ASMN1; SMN2TDP1ATM
SCHEMBL18567268 0.74 TDP1 (0.69) MAPTKMT2ASMN1; SMN2TDP1ATM
SCHEMBL4354033 0.74 PARP10 (0.54) MAPTKMT2ASMN1; SMN2TDP1PRSS1
SCHEMBL20592017 0.74 MAPT (0.56) MAPTKMT2ASMN1; SMN2TDP1L3MBTL1
SCHEMBL28507416 0.73 MAPT (0.56) MAPTKMT2ASMN1; SMN2TDP1ATM
SCHEMBL6258711 0.73 GABRA1 (0.50) TDP1HSD17B10ELANE
SCHEMBL28701907 0.73 RXRA (0.56) MAPTKMT2ASMN1; SMN2TDP1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4638083-A ESTERIFICATION OF HYDROXY COMPOUND WITH ETHYNYL BENZOYL CHLORIDE THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS & SPACE ADMINISTRATION (US) 1987-01-20 US claimed
US-4567240-A Ethynyl terminated ester oligomers and polymers therefrom THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 1986-01-28 US claimed
US-7517641-B2 Reacting such as polyether sulfone or carbonyl having haloalkyl substituents with allyl alcoholate or allylphenolate; forming allyl ether groups capable of reacting with peroxide to form crosslinkable epoxy groups; thermal ink jet printing XEROX CORPORATION (US) 2009-04-14 US disclosed
US-20080199810-A1 HIGH PERFORMANCE CURABLE POLYMERS AND PROCESSES FOR THE PREPARATION THEREOF XEROX CORPORATION (US) 2008-08-21 US disclosed
US-7252927-B2 High performance curable polymers and processes for the preparation thereof XEROX CORPORATION (US) 2007-08-07 US disclosed
US-20050154077-A1 High performance curable polymers and processes for the preparation thereof XEROX CORPORATION 2005-07-14 US disclosed
US-6897267-B2 High performance curable polymers and processes for the preparation thereof XEROX CORPORATION (US) 2005-05-24 US disclosed
US-20040229164-A9 High performance curable polymers and processes for the preparation thereof XEROX CORPORATION 2004-11-18 US disclosed
US-20030118940-A1 High performance curable polymers and processes for the preparation thereof XEROX CORPORATION 2003-06-26 US disclosed
US-6365323-B1 CROSSLINKED OR CHAIN EXTENDED BISPHENOL TYPE POLYETHERS, POLYETHER SULFONES AND/OR POLYETHER KETONES WITH PENDANT PHOTOSENSITIVE EPOXY OR ALLYL ETHER GROUPS FOR PHOTORESISTS AND THERMAL INK JET PRINT HEADS XEROX CORPORATION 2002-04-02 US disclosed
US-6323301-B1 FOR FABRICATION OF INK JET PRINTHEADS, DIELECTRICS, PHOTORESISTS XEROX CORPORATION 2001-11-27 US disclosed
US-5945253-A High performance curable polymers and processes for the preparation thereof XEROX CORPORATION (US) 1999-08-31 US disclosed
US-5889077-A Process for direct substitution of high performance polymers with unsaturated ester groups XEROX CORPORATION (US) 1999-03-30 US disclosed
US-5863963-A Halomethylated high performance curable polymers XEROX CORPORATION (US) 1999-01-26 US disclosed
US-5849809-A Hydroxyalkylated high performance curable polymers XEROX CORPORATION (US) 1998-12-15 US disclosed
US-5761809-A Process for substituting haloalkylated polymers with unsaturated ester, ether, and alkylcarboxymethylene groups XEROX CORPORATION (US) 1998-06-09 US disclosed
US-5753783-A Process for haloalkylation of high performance polymers XEROX CORPORATION (US) 1998-05-19 US disclosed
US-5739254-A Process for haloalkylation of high performance polymers XEROX CORPORATION (US) 1998-04-14 US disclosed
US-4638083-A ESTERIFICATION OF HYDROXY COMPOUND WITH ETHYNYL BENZOYL CHLORIDE THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS & SPACE ADMINISTRATION (US) 1987-01-20 US disclosed
US-4567240-A Ethynyl terminated ester oligomers and polymers therefrom THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 1986-01-28 US disclosed