Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 4/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CCR4 | P51679 | 1/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4552620 | 0.86 | ADRB1 (0.41) | ADRB1HTR2CUSP2ALDH1A1TSHR | |
| SCHEMBL18171738 | 0.86 | ACVR1 (0.45) | ADRB1HTR2CHTR3AHTR1ACYP1A2 | |
| SCHEMBL27261095 | 0.84 | ADRB1 (0.42) | ADRB1KDM4EHTR2CUSP2ALDH1A1 | |
| SCHEMBL5745223 | 0.81 | ADRB1 (0.49) | ADRB1KDM4EUSP2ALDH1A1TSHR | |
| SCHEMBL27202087 | 0.79 | ALDH1A1 (0.54) | ADRB1KDM4EUSP2ALDH1A1TSHR | |
| Benzene SCHEMBL27642991 | 0.76 | HTR6 (0.48) | ADRB1KDM4EUSP2ALDH1A1TSHR | |
| SCHEMBL27107055 | 0.75 | ADRB1 (0.63) | ADRB1KDM4EHTR2CUSP2ALDH1A1 | |
| SCHEMBL3026661 | 0.75 | KDM4E (0.38) | ADRB1KDM4EHTR2CUSP2ALDH1A1 | |
| Phenylpiperazine SCHEMBL27467493 | 0.74 | ADRB1 (0.61) | ADRB1KDM4EHTR2CUSP2ALDH1A1 | |
| SCHEMBL27629620 | 0.74 | ADRB1 (0.67) | ADRB1HTR6HTR3AHTR1ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118261-A1 | QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118261-A1 | QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | BRAF, RAF1, ARAF | ADRB1 1545/4885KDM4E 2197/4885HTR2C 4594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.