Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 3/20 | 0.39 |
| ▸ | ACACA | Q13085 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4365923 | 0.88 | HRH3 (0.59) | HRH3TMEM97SIGMAR1ACACBACACA | |
| SCHEMBL4364219 | 0.83 | SIGMAR1 (0.43) | HRH3SIGMAR1ACACBACACAKDM4E | |
| SCHEMBL3541201 | 0.75 | HRH3 (0.74) | HRH3CNR2ACACBACACA | |
| SCHEMBL4366003 | 0.73 | HRH3 (0.53) | HRH3F10 | |
| SCHEMBL27760334 | 0.67 | HRH3 (0.57) | HRH3CNR2KDM4EALDH1A1 | |
| SCHEMBL3541739 | 0.67 | HRH3 (0.57) | HRH3CNR2KDM4EALDH1A1 | |
| SCHEMBL28306098 | 0.67 | CCR2 (0.66) | CNR2ALDH1A1 | |
| SCHEMBL3539042 | 0.67 | HRH3 (0.59) | HRH3KDM4EALDH1A1 | |
| SCHEMBL4361046 | 0.66 | PROKR1 (0.43) | — | |
| SCHEMBL3539590 | 0.66 | HRH3 (0.60) | HRH3CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010487-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. Hoffmann-Roche AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007115938-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |