Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.53 |
| ▸ | F10 | P00742 | 11/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4365923 | 0.85 | HRH3 (0.59) | HRH3F10 | |
| SCHEMBL4363405 | 0.80 | HRH3 (0.46) | HRH3 | |
| SCHEMBL4364693 | 0.76 | HRH3 (0.49) | HRH3F10 | |
| SCHEMBL3539379 | 0.75 | HRH3 (0.71) | HRH3 | |
| SCHEMBL4364219 | 0.74 | SIGMAR1 (0.43) | HRH3 | |
| SCHEMBL4373527 | 0.73 | HRH3 (0.44) | HRH3F10 | |
| SCHEMBL5017103 | 0.69 | HRH3 (1.00) | HRH3 | |
| SCHEMBL4361046 | 0.68 | PROKR1 (0.43) | — | |
| SCHEMBL4566872 | 0.68 | HRH3 (0.48) | HRH3F10 | |
| SCHEMBL3537401 | 0.68 | HRH3 (0.57) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010487-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. Hoffmann-Roche AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007115938-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |