SCHEMBL436135

SCHEMBL436135

C=Cc1ccc(C#C[Si](C)(C)C)cc1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.46
TSHR P16473 1/20 0.36
HDAC8 Q9BY41 2/20 0.35
CHRNB2 P17787 1/20 0.33
CHRNB4 P30926 1/20 0.33
CHRNA3 P32297 1/20 0.33
CHRNA7 P36544 1/20 0.33
CHRNA4 P43681 1/20 0.33
TDP1 Q9NUW8 1/20 0.32
GABRA1 P14867 1/20 0.32
GABRG2 P18507 1/20 0.32
GABRB3 P28472 1/20 0.32
GABRA5 P31644 1/20 0.32
GABRA3 P34903 1/20 0.32
GABRA2 P47869 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6006594 0.83 FFAR1 (0.37) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL6006591 0.83 FFAR1 (0.37) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL1306384 0.82 GABRA1 (0.38) ALDH1A1TSHRGABRA1GABRG2GABRB3
SCHEMBL27896903 0.81 GABRA1 (0.33) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL1306505 0.79 APP (0.41) ALDH1A1GABRA1GABRG2GABRB3GABRA5
SCHEMBL701214 0.79 CYP2A6 (0.43) ALDH1A1GABRA1GABRG2GABRB3GABRA5
SCHEMBL6517721 0.79 GABRA1 (0.32) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL28337839 0.79 ALDH1A1 (0.41) ALDH1A1TSHRHDAC8CHRNB2CHRNB4
SCHEMBL28340126 0.79 ALDH1A1 (0.41) ALDH1A1TSHRHDAC8CHRNB2CHRNB4
SCHEMBL32667788 0.76 FBP1 (0.34) ALDH1A1GABRA1GABRG2GABRB3GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11719709-B2 Water soluble polymer surfactant for synthesis of functionalized polystyrene nanobeads towards detection of bilirubin in human serum COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2023-08-08 US claimed
CN-113061203-B Catalyst and preparation method thereof, and preparation method of styrene monomer isotactic polymer 中国科学院长春应用化学研究所 2022-03-29 CN claimed
CN-110218220-B Functionalized metal-organic framework compound, complex formed by functionalized metal-organic framework compound, and preparation method and application of functionalized metal-organic framework compound 中山大学 2021-11-12 CN claimed
US-20210255206-A1 Water Soluble Polymer Surfactant for Synthesis of Functionalized Polystyrene Nanobeads Towards Detection of Bilirubin in Human Serum COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2021-08-19 US claimed
CN-113061203-A Catalyst and preparation method thereof, and preparation method of styrene monomer isotactic polymer 中国科学院长春应用化学研究所 2021-07-02 CN claimed
CN-110591025-A Double-lithium-initiated double-end functionalized triblock styrene-diene-styrene polymer and preparation method thereof 大连理工大学 2019-12-20 CN claimed
EP-1551885-B1 PROCESS TO MODIFY POLYMERIC MATERIALS 3M INNOVATIVE PROPERTIES CO (US) 2016-02-17 EP claimed
US-20100048819-A1 PROCESS TO MODIFY POLYMERIC MATERIALS AND RESULTING COMPOSITIONS 3M INNOVATIVE PROPERTIES COMPANY 2010-02-25 US claimed
US-7632916-B2 Thermally induced graft polymerization in an apparatus by shearing, devolatilization; grafting isoprene-t-butyl methacrylate copolymer with polyoxyethylene glycol methyl ether, forming methacrylic acid/anhydride monomers 3M INNOVATIVE PROPERTIES COMPANY (US) 2009-12-15 US claimed
CN-100387624-C Process to modify polymeric materials and resulting compositions 3M INNOVATIVE PROPERTIES CO (US) 2008-05-14 CN claimed
US-7157283-B2 Continuous process for the production of combinatorial libraries of modified materials 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-01-02 US claimed
EP-1551885-A2 PROCESS TO MODIFY POLYMERIC MATERIALS AND RESULTING COMPOSITIONS 3M Innovative Properties Company (US) 2005-07-13 EP claimed
EP-1551547-A1 A CONTINUOUS PROCESS FOR THE PRODUCTION OF COMBINATORIAL LIBRARIES OF MODIFIED MATERIALS 3M Innovative Properties Company (US) 2005-07-13 EP claimed
WO-2004012858-A1 A CONTINUOUS PROCESS FOR THE PRODUCTION OF COMBINATORIAL LIBRARIES OF MODIFIED MATERIALS 3M INNOVATIVE PROPERTIES COMPANY (US) 2004-02-12 WO claimed
WO-2004013189-A2 PROCESS TO MODIFY POLYMERIC MATERIALS AND RESULTING COMPOSITIONS 3M INNOVATIVE PROPERTIES COMPANY (US) 2004-02-12 WO claimed
US-20040023398-A1 Continuous process for the production of combinatorial libraries of modified materials 3M INNOVATIVE PROPERTIES COMPANY 2004-02-05 US claimed
US-20040024130-A1 Process to modify polymeric materials and resulting compositions 3M INNOVATIVE PROPERTIES COMPANY 2004-02-05 US claimed
JP-4335003-A None JP disclosed
US-20040023398-A1 Continuous process for the production of combinatorial libraries of modified materials 3M INNOVATIVE PROPERTIES COMPANY 2004-02-05 US disclosed
JP-H04335003-A POLY(4-ETHYNYLSTYRENE), INTERMEDIATE THEREFOR, AND BLOCK COPOLYMER THEREOF NIPPON ZEON CO LTD 1992-11-24 JP disclosed